Residual small artery impairment in hypertensive patients with normal albumin-creatinine ratio

Objectives Previous studies have suggested that urine albumin excretion (UAE) mirrors generalized vascular damage; however, it is unclear to which degree UAE mirrors small artery impairment. Design We enrolled 67 patients with uncomplicated essential hypertension (EH) during stable antihypertensive therapy. F-Rmin, ACR on three non-consecutive morning urine samples, pulse wave velocity (PWV), and 24-h ambulatory blood pressure (ABPM) were measured. Results ACR was low (0.39 and 0.30-0.60), but abnormal small artery structure defined as F-Rmin > mean + 2 standard deviations of normotensive value (1.99 + 1 mmHg min/(ml/100 ml)) was present in 45% (n = 30). The mean F-Rmin was 2.89 ± 0.09 mmHg min/(ml/100 ml). ACR correlated significantly to PWV (r(2 )=( )0.11; p < 0.05) and pulse pressure (r(2 )=( )0.15; p < 0.001), but not F-Rmin and (r(2 )=( )0.05, p = 0.07). Conclusions Abnormal microvascular structure was present even in EH patients with low UAE. ACR correlated to arterial stiffness and not to small artery structure; therefore, UEA did not reflect microvascular damage in this population. ACR and F-Rmin thus reflect two distinct types of subclinical organ damage in hypertension..

Medienart:	Artikel

Erscheinungsjahr:	2016
Erschienen:	2016

Enthalten in:	Zur Gesamtaufnahme - volume:50
Enthalten in:	Scandinavian cardiovascular journal / Supplement - 50(2016), 3, Seite 167

Sprache:	Englisch

Beteiligte Personen:	Eftekhari, Ashkan [VerfasserIn] Wiggers, Signe Nielsen [Sonstige Person] Mathiassen, Ole Norling [Sonstige Person] Christensen, Kent Lodberg [Sonstige Person]

Links:	www.ncbi.nlm.nih.gov

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC1977496431