In vivo diagnosis with purified tropomyosin in mite and shellfish allergic patients
Tropomyosin is the most studied shellfish allergen and has been involved in cross-reactivity among different invertebrates (crustacean, mollusks, mites, insects, and nematodes). To determine the relevance of tropomyosin in mite- and shellfish-sensitized patients using tropomyosin skin testing. Patients were divided into 3 groups: group M included mite allergic patients (ie, individuals with respiratory symptoms and a positive result on skin prick testing [SPT] to house dust mites), group S included shellfish allergic patients (ie, individuals who reported symptoms with shellfish), and group MS included mite- and shellfish allergic patients (ie, individuals who simultaneously fulfilled the inclusion criteria for groups M and S). Tropomyosin was purified from shrimp, characterized, and used in SPT for diagnosis in the patient population. Eight hundred fifty patients were included in the study: 790 (92.9%) in group M, 21 (2.5%) in group S, and 39 (4.6%) in group MS. Tropomyosin was purified from shrimp with a purity higher than 95%. Forty-two individuals tested positive to tropomyosin: the prevalence was 2.7% in group M, 28.6% in group S, and 38.5% in patients of group MS. Twenty-one (50%) of the tropomyosin-positive individuals had symptoms with shellfish, and 3 (14.3%) reported anaphylaxis. The prevalence of tropomyosin was low in mite-sensitized patients (2.7 %) and high in shellfish allergic patients (28.6%). The higher prevalence of tropomyosin was found in patients sensitized to both mite and shellfish (38.5%). The selection of tropomyosin-sensitized patients by SPT might help in the choice of appropriate treatments or management for these patients..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:116 |
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| Enthalten in: |
Annals of allergy, asthma, & immunology - 116(2016), 6, Seite 538-543 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
López-Matas, M Angeles [VerfasserIn] |
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| Links: |
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| doi: |
10.1016/j.anai.2016.03.034 |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a In vivo diagnosis with purified tropomyosin in mite and shellfish allergic patients |
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| 520 | |a Tropomyosin is the most studied shellfish allergen and has been involved in cross-reactivity among different invertebrates (crustacean, mollusks, mites, insects, and nematodes). To determine the relevance of tropomyosin in mite- and shellfish-sensitized patients using tropomyosin skin testing. Patients were divided into 3 groups: group M included mite allergic patients (ie, individuals with respiratory symptoms and a positive result on skin prick testing [SPT] to house dust mites), group S included shellfish allergic patients (ie, individuals who reported symptoms with shellfish), and group MS included mite- and shellfish allergic patients (ie, individuals who simultaneously fulfilled the inclusion criteria for groups M and S). Tropomyosin was purified from shrimp, characterized, and used in SPT for diagnosis in the patient population. Eight hundred fifty patients were included in the study: 790 (92.9%) in group M, 21 (2.5%) in group S, and 39 (4.6%) in group MS. Tropomyosin was purified from shrimp with a purity higher than 95%. Forty-two individuals tested positive to tropomyosin: the prevalence was 2.7% in group M, 28.6% in group S, and 38.5% in patients of group MS. Twenty-one (50%) of the tropomyosin-positive individuals had symptoms with shellfish, and 3 (14.3%) reported anaphylaxis. The prevalence of tropomyosin was low in mite-sensitized patients (2.7 %) and high in shellfish allergic patients (28.6%). The higher prevalence of tropomyosin was found in patients sensitized to both mite and shellfish (38.5%). The selection of tropomyosin-sensitized patients by SPT might help in the choice of appropriate treatments or management for these patients. | ||
| 540 | |a Nutzungsrecht: Copyright © 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. | ||
| 700 | 1 | |a de Larramendi, Carlos H |4 oth | |
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| 700 | 1 | |a Ferrer, Angel |4 oth | |
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| 700 | 1 | |a Flores, Isabel |4 oth | |
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| 700 | 1 | |a García-Abujeta, José Luis |4 oth | |
| 700 | 1 | |a Vicario, Sandra |4 oth | |
| 700 | 1 | |a Andreu, Carmen |4 oth | |
| 700 | 1 | |a Peña, Maribel |4 oth | |
| 700 | 1 | |a Carnés, Jerónimo |4 oth | |
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