Prognostic value of antibodies to Merkel cell polyomavirus T antigens and VP1 protein in patients with Merkel cell carcinoma
What's already known about this topic? Antibodies against the Merkel cell polyomavirus major capsid VP1 protein are reported to be associated with recurrence in patients with Merkel cell carcinoma, but any association with mortality is unknown. Antibodies directed against T antigens are reported to be associated with disease progression, but their prognostic value is unclear. What does this study add? T‐antigen antibodies at baseline in patients with Merkel cell carcinoma were not associated with outcome. Antibodies against VP1 at baseline were associated with both recurrence and mortality. Linked Comment: Singh and Calonje. Br J Dermatol 2016; 174: 715–716 ..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:174 |
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| Enthalten in: |
The British journal of dermatology - 174(2016), 4, Seite 813-822 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Samimi, M [VerfasserIn] |
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| Links: |
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| doi: |
10.1111/bjd.14313 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Prognostic value of antibodies to Merkel cell polyomavirus T antigens and VP1 protein in patients with Merkel cell carcinoma |
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| 520 | |a What's already known about this topic? Antibodies against the Merkel cell polyomavirus major capsid VP1 protein are reported to be associated with recurrence in patients with Merkel cell carcinoma, but any association with mortality is unknown. Antibodies directed against T antigens are reported to be associated with disease progression, but their prognostic value is unclear. What does this study add? T‐antigen antibodies at baseline in patients with Merkel cell carcinoma were not associated with outcome. Antibodies against VP1 at baseline were associated with both recurrence and mortality. Linked Comment: Singh and Calonje. Br J Dermatol 2016; 174: 715–716 . | ||
| 540 | |a Nutzungsrecht: © 2015 British Association of Dermatologists | ||
| 540 | |a © 2015 British Association of Dermatologists. | ||
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