Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases
Endoplasmic reticulum is a principal organelle responsible for folding, post-translational modifications and transport of secretory, luminal and membrane proteins, thus palys an important rale in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) is a condition that is accelerated by accumulation of unfolded/misfolded proteins after endoplasmic reticulum environment disturbance, triggered by a variety of physiological and pathological factors, such as nutrient deprivation, altered glycosylation, calcium depletion, oxidative stress, DNA damage and energy disturbance, etc. ERS may initiate the unfolded protein response (UPR) to restore cellular homeostasis or lead to apoptosis. Numerous studies have clarified the link between ERS and cardiovascular diseases. This review focuses on ERS-associated molecular mechanisms that participate in physiological and pathophysiological processes of heart and blood vessels. In addition, a number of drugs that regulate ERS was introduced, which may be used to treat cardiovascular diseases. This review may open new avenues for studying the pathogenesis of cardiovascular diseases and discovering novel drugs targeting ERS..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
|---|---|
| Enthalten in: |
Acta pharmacologica Sinica - 37(2016), 4, Seite 425 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Liu, Mei-Qing [VerfasserIn] |
|---|
| Links: |
|---|
| doi: |
10.1038/aps.2015.145 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC1975434854 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1975434854 | ||
| 003 | DE-627 | ||
| 005 | 20230714192152.0 | ||
| 007 | tu | ||
| 008 | 160609s2016 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1038/aps.2015.145 |2 doi | |
| 028 | 5 | 2 | |a PQ20160610 |
| 035 | |a (DE-627)OLC1975434854 | ||
| 035 | |a (DE-599)GBVOLC1975434854 | ||
| 035 | |a (PRQ)p512-ee415c57173074b6255f930a42e39f69c9d46abfe7266063dab9e3db2529a1293 | ||
| 035 | |a (KEY)0110437320160000037000400425endoplasmicreticulumstressanovelmechanismandtherap | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q DNB |
| 084 | |a PHARM |2 fid | ||
| 100 | 1 | |a Liu, Mei-Qing |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a Endoplasmic reticulum is a principal organelle responsible for folding, post-translational modifications and transport of secretory, luminal and membrane proteins, thus palys an important rale in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) is a condition that is accelerated by accumulation of unfolded/misfolded proteins after endoplasmic reticulum environment disturbance, triggered by a variety of physiological and pathological factors, such as nutrient deprivation, altered glycosylation, calcium depletion, oxidative stress, DNA damage and energy disturbance, etc. ERS may initiate the unfolded protein response (UPR) to restore cellular homeostasis or lead to apoptosis. Numerous studies have clarified the link between ERS and cardiovascular diseases. This review focuses on ERS-associated molecular mechanisms that participate in physiological and pathophysiological processes of heart and blood vessels. In addition, a number of drugs that regulate ERS was introduced, which may be used to treat cardiovascular diseases. This review may open new avenues for studying the pathogenesis of cardiovascular diseases and discovering novel drugs targeting ERS. | ||
| 700 | 1 | |a Chen, Zhe |4 oth | |
| 700 | 1 | |a Chen, Lin-Xi |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Acta pharmacologica Sinica |d Basingstoke : Springer Nature, 1995 |g 37(2016), 4, Seite 425 |w (DE-627)224846531 |w (DE-600)1360774-1 |w (DE-576)435516264 |x 1671-4083 |7 nnns |
| 773 | 1 | 8 | |g volume:37 |g year:2016 |g number:4 |g pages:425 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1038/aps.2015.145 |3 Volltext |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/26838072 |
| 856 | 4 | 2 | |u http://search.proquest.com/docview/1777466474 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a FID-PHARM | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a SSG-OPC-PHA | ||
| 912 | |a GBV_ILN_20 | ||
| 912 | |a GBV_ILN_4219 | ||
| 951 | |a AR | ||
| 952 | |d 37 |j 2016 |e 4 |h 425 | ||