Leukocyte telomere length in newborns: implications for the role of telomeres in human disease
In adults, leukocyte telomere length (LTL) is variable, familial, and longer in women and in offspring conceived by older fathers. Although short LTL is associated with atherosclerotic cardiovascular disease, long LTL is associated with major cancers. The prevailing notion is that LTL is a "telomeric clock," whose movement (expressed in LTL attrition) reflects the pace of aging. Accordingly, individuals with short LTL are considered to be biologically older than their peers. Recent studies suggest that LTL is largely determined before adulthood. We examined whether factors that largely characterize LTL in adults also influence LTL in newborns. LTL was measured in blood samples from 490 newborns and their parents. LTL (mean ± SD) was longer (9.50 ± 0.70 kb) in newborns than in their mothers (7.92 ± 0.67 kb) and fathers (7.70 ± 0.71 kb) (both P < .0001); there was no difference in the variance of LTL among the 3 groups. Newborn LTL correlated more strongly with age-adjusted LTL in mothers (r = 0.47; P < .01) than in fathers (r = 0.36; P < .01) (P for interaction = .02). Newborn LTL was longer by 0.144 kb in girls than in boys (P = .02), and LTL was longer by 0.175 kb in mothers than in fathers (P < .0001). For each 1-year increase in father's age, newborn LTL increased by 0.016 kb (95% confidence interval: 0.04 to 0.28) (P = .0086). The large LTL variation across newborns challenges the telomeric clock model. Having inherently short or long LTL may be largely determined at birth, anteceding by decades disease manifestation in adults..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:137 |
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| Enthalten in: |
Pediatrics - 137(2016), 4, Seite 1 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
McKeague, Ian [VerfasserIn] |
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Analysis |
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OLC1974578461 |
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| 520 | |a In adults, leukocyte telomere length (LTL) is variable, familial, and longer in women and in offspring conceived by older fathers. Although short LTL is associated with atherosclerotic cardiovascular disease, long LTL is associated with major cancers. The prevailing notion is that LTL is a "telomeric clock," whose movement (expressed in LTL attrition) reflects the pace of aging. Accordingly, individuals with short LTL are considered to be biologically older than their peers. Recent studies suggest that LTL is largely determined before adulthood. We examined whether factors that largely characterize LTL in adults also influence LTL in newborns. LTL was measured in blood samples from 490 newborns and their parents. LTL (mean ± SD) was longer (9.50 ± 0.70 kb) in newborns than in their mothers (7.92 ± 0.67 kb) and fathers (7.70 ± 0.71 kb) (both P < .0001); there was no difference in the variance of LTL among the 3 groups. Newborn LTL correlated more strongly with age-adjusted LTL in mothers (r = 0.47; P < .01) than in fathers (r = 0.36; P < .01) (P for interaction = .02). Newborn LTL was longer by 0.144 kb in girls than in boys (P = .02), and LTL was longer by 0.175 kb in mothers than in fathers (P < .0001). For each 1-year increase in father's age, newborn LTL increased by 0.016 kb (95% confidence interval: 0.04 to 0.28) (P = .0086). The large LTL variation across newborns challenges the telomeric clock model. Having inherently short or long LTL may be largely determined at birth, anteceding by decades disease manifestation in adults. | ||
| 650 | 4 | |a Diseases | |
| 650 | 4 | |a Health aspects | |
| 650 | 4 | |a Infants (Newborn) | |
| 650 | 4 | |a Analysis | |
| 650 | 4 | |a Risk factors | |
| 650 | 4 | |a Leukocytes | |
| 650 | 4 | |a Newborn babies | |
| 650 | 4 | |a Correlation analysis | |
| 650 | 4 | |a Leucocytes | |
| 650 | 4 | |a Cardiovascular disease | |
| 700 | 1 | |a Aviv, Abraham |4 oth | |
| 700 | 1 | |a Kimura, Masayuki |4 oth | |
| 700 | 1 | |a Wapner, Ronald |4 oth | |
| 700 | 1 | |a Hoffman, Matthew |4 oth | |
| 700 | 1 | |a Kark, Jeremy D |4 oth | |
| 700 | 1 | |a Kezios, Katrina |4 oth | |
| 700 | 1 | |a Susser, Ezra |4 oth | |
| 700 | 1 | |a Factor-Litvak, Pam |4 oth | |
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