Tracheal and Crico-Tracheal Resection and Anastomosis for Malignancies Involving the Thyroid Gland and the Airway
To evaluate outcomes in different malignancies involving the thyroid and infiltrating the airway submitted to tracheal (TRA) or crico-tracheal resection and anastomosis (CTRA). Retrospective charts review of 27 patients affected by thyroid malignancies involving the airway treated by TRA/CTRA in a single academic institution. Kaplan-Meier curves were used to evaluate the overall (OS) and disease-specific (DSS) survivals and local (LC) and loco-regional control (LRC). Impact on survival of age, comorbidities, previous radiotherapy, types of TRA/CTRA, Shin's stage (II, III, IV), grading (well vs poorly differentiated), and length of airway resected was calculated by the log-rank test. Overall survival and DSS at 3 and 5 years were 82.3% and 71.6%, respectively. Local control and LRC in the entire group were 82.3% at 3 and 5 years. Crico-tracheal resection and anastomosis involving the cricoid arch and plate (type C) and tumor differentiation significantly affected OS and DSS (both P < .001). Type C CTRA and tumor differentiation significantly impacted on LC (P = .002 and P = .009, respectively). Grading and extension of CTRA to the cricoid plate are the most important factors for oncologic outcomes in thyroid malignancies infiltrating the airway. Except for poorly differentiated tumors, TRA/CTRA allows adequate LC even in advanced stage lesions involving the crico-tracheal junction..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:125 |
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| Enthalten in: |
The annals of otology, rhinology and laryngology - 125(2016), 2, Seite 97-104 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Piazza, Cesare [VerfasserIn] |
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| Links: |
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| doi: |
10.1177/0003489415599000 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC1971984337 |
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| 245 | 1 | 0 | |a Tracheal and Crico-Tracheal Resection and Anastomosis for Malignancies Involving the Thyroid Gland and the Airway |
| 264 | 1 | |c 2016 | |
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| 520 | |a To evaluate outcomes in different malignancies involving the thyroid and infiltrating the airway submitted to tracheal (TRA) or crico-tracheal resection and anastomosis (CTRA). Retrospective charts review of 27 patients affected by thyroid malignancies involving the airway treated by TRA/CTRA in a single academic institution. Kaplan-Meier curves were used to evaluate the overall (OS) and disease-specific (DSS) survivals and local (LC) and loco-regional control (LRC). Impact on survival of age, comorbidities, previous radiotherapy, types of TRA/CTRA, Shin's stage (II, III, IV), grading (well vs poorly differentiated), and length of airway resected was calculated by the log-rank test. Overall survival and DSS at 3 and 5 years were 82.3% and 71.6%, respectively. Local control and LRC in the entire group were 82.3% at 3 and 5 years. Crico-tracheal resection and anastomosis involving the cricoid arch and plate (type C) and tumor differentiation significantly affected OS and DSS (both P < .001). Type C CTRA and tumor differentiation significantly impacted on LC (P = .002 and P = .009, respectively). Grading and extension of CTRA to the cricoid plate are the most important factors for oncologic outcomes in thyroid malignancies infiltrating the airway. Except for poorly differentiated tumors, TRA/CTRA allows adequate LC even in advanced stage lesions involving the crico-tracheal junction. | ||
| 540 | |a Nutzungsrecht: © The Author(s) 2015. | ||
| 650 | 4 | |a Tracheotomy - methods | |
| 650 | 4 | |a Cricoid Cartilage - surgery | |
| 650 | 4 | |a Anastomosis, Surgical - methods | |
| 650 | 4 | |a Airway Obstruction - etiology | |
| 650 | 4 | |a Thyroid Neoplasms - complications | |
| 650 | 4 | |a Thyroidectomy - methods | |
| 650 | 4 | |a Tomography, X-Ray Computed - methods | |
| 650 | 4 | |a Trachea - surgery | |
| 650 | 4 | |a Thyroid Neoplasms - mortality | |
| 650 | 4 | |a Magnetic Resonance Imaging - methods | |
| 650 | 4 | |a Cricoid Cartilage - pathology | |
| 650 | 4 | |a Thyroid Neoplasms - pathology | |
| 650 | 4 | |a Thyroid Neoplasms - diagnosis | |
| 650 | 4 | |a Thyroid Neoplasms - surgery | |
| 650 | 4 | |a Tracheotomy - adverse effects | |
| 650 | 4 | |a Thyroidectomy - adverse effects | |
| 650 | 4 | |a Airway Obstruction - diagnosis | |
| 650 | 4 | |a Biopsy, Fine-Needle - methods | |
| 650 | 4 | |a Trachea - pathology | |
| 650 | 4 | |a Endoscopy - methods | |
| 650 | 4 | |a Airway Obstruction - surgery | |
| 700 | 1 | |a Del Bon, Francesca |4 oth | |
| 700 | 1 | |a Barbieri, Diego |4 oth | |
| 700 | 1 | |a Grazioli, Paola |4 oth | |
| 700 | 1 | |a Paderno, Alberto |4 oth | |
| 700 | 1 | |a Perotti, Pietro |4 oth | |
| 700 | 1 | |a Lombardi, Davide |4 oth | |
| 700 | 1 | |a Peretti, Giorgio |4 oth | |
| 700 | 1 | |a Nicolai, Piero |4 oth | |
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| 856 | 4 | 1 | |u http://dx.doi.org/10.1177/0003489415599000 |3 Volltext |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/26296930 |
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