Increased Baseline C-Reactive Protein Concentrations Are Associated with Increased Risk of Infections: Results from 2 Large Danish Population Cohorts
The acute-phase reactant C-reactive protein (CRP) increases rapidly during an infection. We tested the hypothesis that chronic low-level increases in CRP are associated with an increased risk of infectious disease. We studied 9660 individuals from a prospective general population cohort, including 3592 in whom infectious disease developed, and another 60 896 individuals from a cross-sectional general population study, of whom 13 332 developed infectious disease; 55% were women, and the mean age was 57 years. Hospital diagnoses of infections in 1977-2010 were based on International Classification of Diseases-coded discharge records from the national Danish Patient Registry. We measured CRP concentrations and conducted genotyping for 4 CRP polymorphisms that increase CRP. Individuals with CRP >10 mg/L were excluded because of possible ongoing infection at the time of testing. Individuals with CRP >3 mg/L had 1.2 and 1.7 times increased risk of infectious disease, in the prospective general population cohort and the cross-sectional general population study, respectively, compared with individuals with CRP <1 mg/L. In the combined populations, individuals in the highest CRP tertile (compared with the lowest) had an increased risk of bacterial diseases (hazard ratio 1.7, 95% CI 1.6-1.8), but not viral, mycosis, and parasitic diseases. The increased risk was mainly carried by pneumonia, sepsis, and particularly gram-negative infections. None of the genotype combinations examined conferred an increased risk of infectious disease. Chronic low-level CRP increases were associated with increased risk of bacterial infections, gram-negative infections in particular. Genotypes associated with increases in CRP were not associated with increased risk of infection..
Medienart: |
Artikel |
---|
Erscheinungsjahr: |
2016 |
---|---|
Erschienen: |
2016 |
Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
---|---|
Enthalten in: |
Clinical chemistry - 62(2016), 2, Seite 335-342 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Benfield, Thomas [VerfasserIn] |
---|
Links: |
---|
Themen: |
Alcohol |
---|
doi: |
10.1373/clinchem.2015.249680 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
OLC197183601X |
---|
LEADER | 01000caa a2200265 4500 | ||
---|---|---|---|
001 | OLC197183601X | ||
003 | DE-627 | ||
005 | 20230714182239.0 | ||
007 | tu | ||
008 | 160308s2016 xx ||||| 00| ||eng c | ||
024 | 7 | |a 10.1373/clinchem.2015.249680 |2 doi | |
028 | 5 | 2 | |a PQ20160307 |
035 | |a (DE-627)OLC197183601X | ||
035 | |a (DE-599)GBVOLC197183601X | ||
035 | |a (PRQ)c1204-a35c07f07e14954e57553ec59029981f9caba37217bd41f3ba6b1b2c3ef8543b0 | ||
035 | |a (KEY)0055889320160000062000200335increasedbaselinecreactiveproteinconcentrationsare | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | 4 | |a 540 |a 610 |q DNB |
100 | 1 | |a Benfield, Thomas |e verfasserin |4 aut | |
245 | 1 | 0 | |a Increased Baseline C-Reactive Protein Concentrations Are Associated with Increased Risk of Infections: Results from 2 Large Danish Population Cohorts |
264 | 1 | |c 2016 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
520 | |a The acute-phase reactant C-reactive protein (CRP) increases rapidly during an infection. We tested the hypothesis that chronic low-level increases in CRP are associated with an increased risk of infectious disease. We studied 9660 individuals from a prospective general population cohort, including 3592 in whom infectious disease developed, and another 60 896 individuals from a cross-sectional general population study, of whom 13 332 developed infectious disease; 55% were women, and the mean age was 57 years. Hospital diagnoses of infections in 1977-2010 were based on International Classification of Diseases-coded discharge records from the national Danish Patient Registry. We measured CRP concentrations and conducted genotyping for 4 CRP polymorphisms that increase CRP. Individuals with CRP >10 mg/L were excluded because of possible ongoing infection at the time of testing. Individuals with CRP >3 mg/L had 1.2 and 1.7 times increased risk of infectious disease, in the prospective general population cohort and the cross-sectional general population study, respectively, compared with individuals with CRP <1 mg/L. In the combined populations, individuals in the highest CRP tertile (compared with the lowest) had an increased risk of bacterial diseases (hazard ratio 1.7, 95% CI 1.6-1.8), but not viral, mycosis, and parasitic diseases. The increased risk was mainly carried by pneumonia, sepsis, and particularly gram-negative infections. None of the genotype combinations examined conferred an increased risk of infectious disease. Chronic low-level CRP increases were associated with increased risk of bacterial infections, gram-negative infections in particular. Genotypes associated with increases in CRP were not associated with increased risk of infection. | ||
540 | |a Nutzungsrecht: © 2015 American Association for Clinical Chemistry. | ||
650 | 4 | |a Heart | |
650 | 4 | |a Alcohol | |
650 | 4 | |a Mortality | |
650 | 4 | |a Funding | |
650 | 4 | |a Plasma | |
650 | 4 | |a Immune system | |
650 | 4 | |a Viral infections | |
650 | 4 | |a Studies | |
650 | 4 | |a Design | |
650 | 4 | |a Inflammation | |
650 | 4 | |a Sepsis | |
650 | 4 | |a Bacterial infections | |
650 | 4 | |a Infectious diseases | |
650 | 4 | |a Hospitalization | |
650 | 4 | |a Population | |
650 | 4 | |a Cytokines | |
650 | 4 | |a Pneumonia | |
650 | 4 | |a Infections | |
700 | 1 | |a Nordestgaard, Børge G |4 oth | |
700 | 1 | |a Tybjærg-Hansen, Anne |4 oth | |
700 | 1 | |a Zacho, Jeppe |4 oth | |
773 | 0 | 8 | |i Enthalten in |t Clinical chemistry |d Washington, DC : American Association for Clinical Chemistry, 1955 |g 62(2016), 2, Seite 335-342 |w (DE-627)129269115 |w (DE-600)80102-1 |w (DE-576)014459558 |x 0009-9147 |7 nnns |
773 | 1 | 8 | |g volume:62 |g year:2016 |g number:2 |g pages:335-342 |
856 | 4 | 1 | |u http://dx.doi.org/10.1373/clinchem.2015.249680 |3 Volltext |
856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/26721294 |
856 | 4 | 2 | |u http://search.proquest.com/docview/1764295609 |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_OLC | ||
912 | |a SSG-OLC-CHE | ||
912 | |a SSG-OLC-PHA | ||
912 | |a SSG-OLC-DE-84 | ||
912 | |a GBV_ILN_31 | ||
912 | |a GBV_ILN_69 | ||
912 | |a GBV_ILN_2006 | ||
912 | |a GBV_ILN_2011 | ||
912 | |a GBV_ILN_4012 | ||
912 | |a GBV_ILN_4112 | ||
912 | |a GBV_ILN_4125 | ||
912 | |a GBV_ILN_4219 | ||
912 | |a GBV_ILN_4305 | ||
951 | |a AR | ||
952 | |d 62 |j 2016 |e 2 |h 335-342 |