Melatonin: resetting the clock of cancer progression?
when these target genes are surveyed in more detail, functional domains including cell replication, DNA repair, cell death, and differentiation emerge quite strongly, to suggest that the "pure flame" originally evoked by Descartes might help modern oncologists to shed light on the molecular progression of cancer. [...]when examined under the appropriate light, in fact, the parallels between the increasing cancer incidence and the increasingly frenetic pace of modern life, becomes perhaps an unsurprising finding. Initial evidence suggests that the addition of melatonin to chemotherapy or radiotherapy schedules improve tolerability by reducing haematological side-effects, neurotoxicity, and fatigue--common dose-limiting toxicities stemming from chemotherapy. [...]the broad antioxidant properties of melatonin have stimulated its consideration in the chemoprevention of cancer..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
The lancet |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pinato, David J [VerfasserIn] |
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| Links: |
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| BKL: | |
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| Themen: |
Anatomy & physiology |
| doi: |
10.1016/S1470-2045(15)00571-9 |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Melatonin: resetting the clock of cancer progression? |
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| 520 | |a when these target genes are surveyed in more detail, functional domains including cell replication, DNA repair, cell death, and differentiation emerge quite strongly, to suggest that the "pure flame" originally evoked by Descartes might help modern oncologists to shed light on the molecular progression of cancer. [...]when examined under the appropriate light, in fact, the parallels between the increasing cancer incidence and the increasingly frenetic pace of modern life, becomes perhaps an unsurprising finding. Initial evidence suggests that the addition of melatonin to chemotherapy or radiotherapy schedules improve tolerability by reducing haematological side-effects, neurotoxicity, and fatigue--common dose-limiting toxicities stemming from chemotherapy. [...]the broad antioxidant properties of melatonin have stimulated its consideration in the chemoprevention of cancer. | ||
| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Cancer therapies | |
| 650 | 4 | |a Drug dosages | |
| 650 | 4 | |a Chemotherapy | |
| 650 | 4 | |a Physiology | |
| 650 | 4 | |a Breast cancer | |
| 650 | 4 | |a Homeostasis | |
| 650 | 4 | |a Circadian rhythm | |
| 650 | 4 | |a Endocrine system | |
| 650 | 4 | |a Anatomy & physiology | |
| 700 | 1 | |a Stebbing, Justin |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t The lancet <London> / Oncology |d Oxford : Elsevier, 2000 |g 17(2016), 1, Seite 23 |w (DE-627)330613073 |w (DE-600)2049730-1 |w (DE-576)100517625 |x 1470-2045 |7 nnns |
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| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/26758751 |
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