Expanded Evidence for Frozen Fecal Microbiota Transplantation for Clostridium difficile Infection: A Fresh Take
By transplanting donor stool into a patient with recurrent Clostridium difficile infection (CDI), fecal microbiota transplantation (FMT) restores the colonic microbiota to a more healthy state. Although the procedure initially received slow acceptance, FMT is performed routinely today, especially after recent data demonstrating efficacy of FMT for recurrent CDI. At present, the best evidence for FMT is for recurrent CDI, although there's increasing evidence for use in severe, complicated, and refractory CDI. Malani and Rao comment on Lee and colleagues' study that presents the results of a randomized noninferiority trial conducted at 6 academic medical centers in Canada comparing frozen and thawed FMT with fresh FMT to treat patients with multiply recurrent CDI or refractory CDI..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:315 |
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| Enthalten in: |
The journal of the American Medical Association / Englische Ausgabe - 315(2016), 2, Seite 137 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rao, Krishna [VerfasserIn] |
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| Links: |
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| Themen: |
Bacterial infections |
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| Förderinstitution / Projekttitel: |
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| 520 | |a By transplanting donor stool into a patient with recurrent Clostridium difficile infection (CDI), fecal microbiota transplantation (FMT) restores the colonic microbiota to a more healthy state. Although the procedure initially received slow acceptance, FMT is performed routinely today, especially after recent data demonstrating efficacy of FMT for recurrent CDI. At present, the best evidence for FMT is for recurrent CDI, although there's increasing evidence for use in severe, complicated, and refractory CDI. Malani and Rao comment on Lee and colleagues' study that presents the results of a randomized noninferiority trial conducted at 6 academic medical centers in Canada comparing frozen and thawed FMT with fresh FMT to treat patients with multiply recurrent CDI or refractory CDI. | ||
| 650 | 4 | |a Diarrhea - therapy | |
| 650 | 4 | |a Enterocolitis, Pseudomembranous - therapy | |
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