Early repolarization and positive T-wave alternans as risk markers for life-threatening arrhythmias in patients with vasospastic angina
Several arrhythmogenic markers have been suggested as predictors for risk of life-threatening arrhythmias during symptom-free periods in vasospastic angina (VSA), but no definite conclusion has been drawn. To investigate prevalence of fatal ventricular tachyarrhythmia in VSA and its relation to appearance of early repolarization (ER) and positive T wave alternans (p-TWA) in patients with VSA during symptom-free periods. We studied 116 consecutive patients with chest pain who underwent an acetylcholine provocation test for VSA diagnosis. Patients were divided into two groups with positive (VSA group; 66 cases) and negative (control group; 50 cases) provocation test results. The presence of ER on electrocardiogram and the modified moving average analysis of TWA during symptom-free periods were explored. The incidences of ER and p-TWA were higher in the VSA than in the control group (P=0.001 and P=0.006, respectively). Multivariate analysis revealed that ER and p-TWA were independent predictors of VSA (odds ratio, 5.65 and 4.94; 95% confidence interval: 1.11-28.9 and 1.22-19.9, respectively). The incidence of coexisting baseline ER and p-TWA was significantly higher in VSA patients with life-threatening arrhythmic events (3/3 vs. 6/38; P<0.001) than in those without. VSA patients with arrhythmic events showed a high incidence of ER and p-TWA during symptom-free periods. Therefore, baseline ER and p-TWA may help to identify VSA patients at high risk for life-threatening arrhythmias..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:196 |
|---|---|
| Enthalten in: |
International journal of cardiology - 196(2015), Seite 7-13 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Suzuki, Makoto [VerfasserIn] |
|---|
| Links: |
|---|
| BKL: |
|---|
| doi: |
10.1016/j.ijcard.2015.05.147 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC196960025X |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC196960025X | ||
| 003 | DE-627 | ||
| 005 | 20220223071706.0 | ||
| 007 | tu | ||
| 008 | 160211s2015 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijcard.2015.05.147 |2 doi | |
| 028 | 5 | 2 | |a PQ20160211 |
| 035 | |a (DE-627)OLC196960025X | ||
| 035 | |a (DE-599)GBVOLC196960025X | ||
| 035 | |a (PRQ)c1282-5254caf5fb6e87fb1164e3c11a434ad871b9a821425791b9611c449d9cfa50a50 | ||
| 035 | |a (KEY)0071511520150000196000000007earlyrepolarizationandpositivetwavealternansasrisk | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q DNB |
| 084 | |a 44.00 |2 bkl | ||
| 100 | 1 | |a Suzuki, Makoto |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Early repolarization and positive T-wave alternans as risk markers for life-threatening arrhythmias in patients with vasospastic angina |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a Several arrhythmogenic markers have been suggested as predictors for risk of life-threatening arrhythmias during symptom-free periods in vasospastic angina (VSA), but no definite conclusion has been drawn. To investigate prevalence of fatal ventricular tachyarrhythmia in VSA and its relation to appearance of early repolarization (ER) and positive T wave alternans (p-TWA) in patients with VSA during symptom-free periods. We studied 116 consecutive patients with chest pain who underwent an acetylcholine provocation test for VSA diagnosis. Patients were divided into two groups with positive (VSA group; 66 cases) and negative (control group; 50 cases) provocation test results. The presence of ER on electrocardiogram and the modified moving average analysis of TWA during symptom-free periods were explored. The incidences of ER and p-TWA were higher in the VSA than in the control group (P=0.001 and P=0.006, respectively). Multivariate analysis revealed that ER and p-TWA were independent predictors of VSA (odds ratio, 5.65 and 4.94; 95% confidence interval: 1.11-28.9 and 1.22-19.9, respectively). The incidence of coexisting baseline ER and p-TWA was significantly higher in VSA patients with life-threatening arrhythmic events (3/3 vs. 6/38; P<0.001) than in those without. VSA patients with arrhythmic events showed a high incidence of ER and p-TWA during symptom-free periods. Therefore, baseline ER and p-TWA may help to identify VSA patients at high risk for life-threatening arrhythmias. | ||
| 540 | |a Nutzungsrecht: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. | ||
| 700 | 1 | |a Fujii, Hiroyuki |4 oth | |
| 700 | 1 | |a Yamawake, Noriyosi |4 oth | |
| 700 | 1 | |a Isobe, Mitsuaki |4 oth | |
| 700 | 1 | |a Nishizaki, Mitsuhiro |4 oth | |
| 700 | 1 | |a Shimizu, Masato |4 oth | |
| 700 | 1 | |a Sakurada, Harumizu |4 oth | |
| 700 | 1 | |a Inamura, Yukihiro |4 oth | |
| 700 | 1 | |a Hiraoka, Masayasu |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cardiology |d Amsterdam : Elsevier, 1981 |g 196(2015), Seite 7-13 |w (DE-627)130542326 |w (DE-600)779519-1 |w (DE-576)016104293 |x 0167-5273 |7 nnns |
| 773 | 1 | 8 | |g volume:196 |g year:2015 |g pages:7-13 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1016/j.ijcard.2015.05.147 |3 Volltext |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/26070177 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4219 | ||
| 912 | |a GBV_ILN_4305 | ||
| 936 | b | k | |a 44.00 |q AVZ |
| 951 | |a AR | ||
| 952 | |d 196 |j 2015 |h 7-13 | ||