Diagnostic Accuracy of Tumor Markers CYFRA21-1 and CA125 in the Differential Diagnosis of Ascites
The usefulness of tumor markers in the differential diagnosis of cancer in patients with ascites remains a matter of controversy. Few studies have reported the measurement of cancer antigen 125 (CA125) and cytokeratin 19 soluble fragments (CYFRA21-1) in ascitic fluid. The aim of the present study was to evaluate the diagnostic accuracy of these tumor markers in the detection of malignant ascites. We analyzed CA125 and CYFRA21-1 from 143 consecutive undiagnosed patients with ascitis. Use of CA125 gave a sensitivity of 39.7% and a specificity of 98.8%, and CYFRA21-1 a sensitivity of 50.0% and a specificity of 97.6% in differential diagnosis of malignant ascites. For combined use of CA125 plus CYFRA21-1, sensitivity was 65.5% and specificity 96.5%. In patients with negative cytology, these two tumor markers had a sensitivity of 50% and a specificity of 96.5%. The determination of tumor markers in ascitic fluid could be useful for the diagnostic assessment of patients with ascites..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
Anticancer research - 35(2015), 10, Seite 5655 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Trapé, Jaume [VerfasserIn] |
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| PPN (Katalog-ID): |
OLC1968607374 |
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| 245 | 1 | 0 | |a Diagnostic Accuracy of Tumor Markers CYFRA21-1 and CA125 in the Differential Diagnosis of Ascites |
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| 520 | |a The usefulness of tumor markers in the differential diagnosis of cancer in patients with ascites remains a matter of controversy. Few studies have reported the measurement of cancer antigen 125 (CA125) and cytokeratin 19 soluble fragments (CYFRA21-1) in ascitic fluid. The aim of the present study was to evaluate the diagnostic accuracy of these tumor markers in the detection of malignant ascites. We analyzed CA125 and CYFRA21-1 from 143 consecutive undiagnosed patients with ascitis. Use of CA125 gave a sensitivity of 39.7% and a specificity of 98.8%, and CYFRA21-1 a sensitivity of 50.0% and a specificity of 97.6% in differential diagnosis of malignant ascites. For combined use of CA125 plus CYFRA21-1, sensitivity was 65.5% and specificity 96.5%. In patients with negative cytology, these two tumor markers had a sensitivity of 50% and a specificity of 96.5%. The determination of tumor markers in ascitic fluid could be useful for the diagnostic assessment of patients with ascites. | ||
| 540 | |a Nutzungsrecht: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. | ||
| 650 | 4 | |a Antigens, Neoplasm - metabolism | |
| 650 | 4 | |a Neoplasms - complications | |
| 650 | 4 | |a Ascites - metabolism | |
| 650 | 4 | |a Ascites - etiology | |
| 650 | 4 | |a CA-125 Antigen - metabolism | |
| 650 | 4 | |a Neoplasms - pathology | |
| 650 | 4 | |a Pleural Effusion, Malignant - etiology | |
| 650 | 4 | |a Pleural Effusion, Malignant - diagnosis | |
| 650 | 4 | |a Keratin-19 - metabolism | |
| 650 | 4 | |a Biomarkers, Tumor - metabolism | |
| 650 | 4 | |a Pleural Effusion, Malignant - metabolism | |
| 650 | 4 | |a Ascites - diagnosis | |
| 650 | 4 | |a Carcinoembryonic Antigen - metabolism | |
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