Neonatal bilirubin binding capacity discerns risk of neurological dysfunction
Bilirubin binding capacity (BBC) defines the dynamic relationship between an infant's level of unbound or "free" bilirubin and his/her ability to "tolerate" increasing bilirubin loads. BBC is not synonymous with albumin (Alb) levels because Alb binding of bilirubin is confounded by a variety of molecular, biologic, and metabolic factors. We utilized a novel modification of a previously developed hematofluorometric method to directly assay BBC in whole blood from preterm and term neonates and then combined these data with an archived database. Total bilirubin (TB) was also measured, and multiple regression modeling was used to determine whether BBC in combination with TB measurements can assess an infant's risk for developing bilirubin-induced neurotoxicity. TB and BBC levels ranged from 0.7-22.8 to 6.3-47.5 mg/dl, respectively. Gestational age (GA) correlated with BBC (r = 0.54; P < 0.0002) with a slope of 0.93 mg/dl/wk by logistic regression. Our calculations demonstrate that recently recommended GA-modulated TB thresholds for phototherapy and exchange transfusion correspond to 45 and 67% saturation of our observed regression line, respectively. We speculate that the spread of BBC levels around the regression line (± 5.8 mg/dl) suggests that individualized BBC assays would provide a robust approach to gauge risk of bilirubin neurotoxicity compared with TB and GA..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:77 |
|---|---|
| Enthalten in: |
Pediatric research - 77(2015), 2, Seite 334 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lamola, Angelo A [VerfasserIn] |
|---|
| Links: |
|---|
| doi: |
10.1038/pr.2014.191 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC1967792461 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1967792461 | ||
| 003 | DE-627 | ||
| 005 | 20230714171516.0 | ||
| 007 | tu | ||
| 008 | 160206s2015 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1038/pr.2014.191 |2 doi | |
| 028 | 5 | 2 | |a PQ20160617 |
| 035 | |a (DE-627)OLC1967792461 | ||
| 035 | |a (DE-599)GBVOLC1967792461 | ||
| 035 | |a (PRQ)c1488-3471230eef07c46b99625f8fe8887c66ba7493373a0ab62c2c591a78166d7c730 | ||
| 035 | |a (KEY)0079756120150000077000200334neonatalbilirubinbindingcapacitydiscernsriskofneur | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 17a |a 26a |a 610 |q DNB |
| 082 | 0 | 4 | |a 610 |q AVZ |
| 100 | 1 | |a Lamola, Angelo A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Neonatal bilirubin binding capacity discerns risk of neurological dysfunction |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a Bilirubin binding capacity (BBC) defines the dynamic relationship between an infant's level of unbound or "free" bilirubin and his/her ability to "tolerate" increasing bilirubin loads. BBC is not synonymous with albumin (Alb) levels because Alb binding of bilirubin is confounded by a variety of molecular, biologic, and metabolic factors. We utilized a novel modification of a previously developed hematofluorometric method to directly assay BBC in whole blood from preterm and term neonates and then combined these data with an archived database. Total bilirubin (TB) was also measured, and multiple regression modeling was used to determine whether BBC in combination with TB measurements can assess an infant's risk for developing bilirubin-induced neurotoxicity. TB and BBC levels ranged from 0.7-22.8 to 6.3-47.5 mg/dl, respectively. Gestational age (GA) correlated with BBC (r = 0.54; P < 0.0002) with a slope of 0.93 mg/dl/wk by logistic regression. Our calculations demonstrate that recently recommended GA-modulated TB thresholds for phototherapy and exchange transfusion correspond to 45 and 67% saturation of our observed regression line, respectively. We speculate that the spread of BBC levels around the regression line (± 5.8 mg/dl) suggests that individualized BBC assays would provide a robust approach to gauge risk of bilirubin neurotoxicity compared with TB and GA. | ||
| 650 | 4 | |a Bilirubin - blood | |
| 650 | 4 | |a Risk Assessment - methods | |
| 650 | 4 | |a Neurotoxicity Syndromes - etiology | |
| 650 | 4 | |a Fluorometry - methods | |
| 650 | 4 | |a Infant, Premature - metabolism | |
| 650 | 4 | |a Neurotoxicity Syndromes - blood | |
| 650 | 4 | |a Bilirubin - metabolism | |
| 650 | 4 | |a Bilirubin - toxicity | |
| 700 | 1 | |a Bhutani, Vinod K |4 oth | |
| 700 | 1 | |a Du, Lizhong |4 oth | |
| 700 | 1 | |a Castillo Cuadrado, Martin |4 oth | |
| 700 | 1 | |a Chen, Lihua |4 oth | |
| 700 | 1 | |a Shen, Zheng |4 oth | |
| 700 | 1 | |a Wong, Ronald J |4 oth | |
| 700 | 1 | |a Stevenson, David K |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric research |d New York : Springer Nature, 1967 |g 77(2015), 2, Seite 334 |w (DE-627)129085146 |w (DE-600)4411-8 |w (DE-576)014418878 |x 0031-3998 |7 nnns |
| 773 | 1 | 8 | |g volume:77 |g year:2015 |g number:2 |g pages:334 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1038/pr.2014.191 |3 Volltext |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/25420178 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a GBV_ILN_252 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4219 | ||
| 951 | |a AR | ||
| 952 | |d 77 |j 2015 |e 2 |h 334 | ||