Effect of dopamine D1 and D2 receptor blockade on the immunostimulating effect of δ1 opioid receptor agonist DPDPE in mice with different psychoemotional states
It is established that activation of delta1 opioid receptors with their selective agonist DPDPE(100 μg/kg) significantly increases IgM immune response not only in C57BL/6J mice with unchanged psychoemotional state, but also in mice displaying aggressive or depressive-like behavior in the social stress model (10 days of agonistic confrontations). SCH-23390 (1.0 mg/kg), selective antagonist of dopamine D1 receptors, and selective D2 receptor blocker haloperidol (1 mg/kg) prevented the immunostimulating effect of DPDPE in animals not subjected to social stress. At the same time, both SCH-23390 and haloperidol did not affect DPDPE-induced immunostimulation in mice engaged in aggressive or depressive-like behaviors..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:78 |
|---|---|
| Enthalten in: |
Ėksperimentalʹnaja i kliničeskaja farmakologija - 78(2015), 1, Seite 27 |
| Sprache: |
Russisch |
|---|
| Beteiligte Personen: |
Cheĭdo, M A [VerfasserIn] |
|---|
| Links: |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
OLC1967401152 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1967401152 | ||
| 003 | DE-627 | ||
| 005 | 20230714170857.0 | ||
| 007 | tu | ||
| 008 | 160206s2015 xx ||||| 00| ||rus c | ||
| 028 | 5 | 2 | |a PQ20160617 |
| 035 | |a (DE-627)OLC1967401152 | ||
| 035 | |a (DE-599)GBVOLC1967401152 | ||
| 035 | |a (PRQ)pubmed_primary_258268710 | ||
| 035 | |a (KEY)0073075020150000078000100027effectofdopamined1andd2receptorblockadeontheimmuno | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a rus | ||
| 082 | 0 | 4 | |a 610 |q DNB |
| 100 | 1 | |a Cheĭdo, M A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of dopamine D1 and D2 receptor blockade on the immunostimulating effect of δ1 opioid receptor agonist DPDPE in mice with different psychoemotional states |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a It is established that activation of delta1 opioid receptors with their selective agonist DPDPE(100 μg/kg) significantly increases IgM immune response not only in C57BL/6J mice with unchanged psychoemotional state, but also in mice displaying aggressive or depressive-like behavior in the social stress model (10 days of agonistic confrontations). SCH-23390 (1.0 mg/kg), selective antagonist of dopamine D1 receptors, and selective D2 receptor blocker haloperidol (1 mg/kg) prevented the immunostimulating effect of DPDPE in animals not subjected to social stress. At the same time, both SCH-23390 and haloperidol did not affect DPDPE-induced immunostimulation in mice engaged in aggressive or depressive-like behaviors. | ||
| 650 | 4 | |a Dopamine Antagonists - pharmacology | |
| 650 | 4 | |a Depression - immunology | |
| 650 | 4 | |a Receptors, Dopamine D2 - metabolism | |
| 650 | 4 | |a Stress, Psychological - immunology | |
| 650 | 4 | |a Receptors, Dopamine D1 - metabolism | |
| 650 | 4 | |a Enkephalin, D-Penicillamine (2,5)- - pharmacology | |
| 650 | 4 | |a Receptors, Opioid, delta - metabolism | |
| 650 | 4 | |a Spleen - drug effects | |
| 650 | 4 | |a Haloperidol - pharmacology | |
| 650 | 4 | |a Erythrocytes - immunology | |
| 650 | 4 | |a Spleen - cytology | |
| 650 | 4 | |a Stress, Psychological - drug therapy | |
| 650 | 4 | |a Immunoglobulin M - biosynthesis | |
| 650 | 4 | |a Aggression - drug effects | |
| 650 | 4 | |a Aggression - psychology | |
| 650 | 4 | |a Benzazepines - pharmacology | |
| 650 | 4 | |a Spleen - immunology | |
| 650 | 4 | |a Analgesics, Opioid - pharmacology | |
| 650 | 4 | |a Depression - drug therapy | |
| 650 | 4 | |a Depression - psychology | |
| 700 | 1 | |a Idova, G V |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Ėksperimentalʹnaja i kliničeskaja farmakologija |d Moskva : Folium, 1992 |g 78(2015), 1, Seite 27 |w (DE-627)131080334 |w (DE-600)1112638-3 |w (DE-576)9131080332 |x 0869-2092 |7 nnns |
| 773 | 1 | 8 | |g volume:78 |g year:2015 |g number:1 |g pages:27 |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/25826871 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a GBV_ILN_4219 | ||
| 951 | |a AR | ||
| 952 | |d 78 |j 2015 |e 1 |h 27 | ||