Advances on Non-CD4 + Foxp3+ T Regulatory Cells: CD8+, Type 1, and Double Negative T Regulatory Cells in Organ Transplantation
The overwhelming body of research on T regulatory cells (Treg) has focused on CD4 + CD25 + Foxp3+ T cells. However, recent years have witnessed a resurgence in interest in CD4 - CD8+, CD4 - CD8- (double negative [DN]), and CD4 + Foxp3- type 1 Treg (Tr1) Treg and their role in controlling autoimmune diseases and in promoting the survival of organ allografts and xenografts. CD8+ and DN Treg can arise spontaneously (natural Treg) or can be induced in situ. Both CD8+ and DN Treg have been shown to enhance the survival of organ allografts and xenografts. Additionally, both can suppress alloimmune responses by contact-dependent mechanisms by either inducing apoptosis or mediating direct cytolysis of effector T cells. CD8+, DN, and Tr1 Treg can also act in a contact-independent manner by elaborating soluble immunosuppressive factors, such as TGF-β and IL-10. Applying CD8+, DN, and Tr1 Treg for enhancing the survival of organ allografts and xenografts is still in its infancy but holds significant potential. Furthermore, there is a need for a more comprehensive understanding of how current immunosuppressive therapies applied to organ transplantations affect the wide array of Treg populations..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:99 |
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| Enthalten in: |
Transplantation - 99(2015), 8, Seite 1553 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ligocki, Ann J [VerfasserIn] |
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| Links: |
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| RVK: |
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| doi: |
10.1097/TP.0000000000000813 |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The overwhelming body of research on T regulatory cells (Treg) has focused on CD4 + CD25 + Foxp3+ T cells. However, recent years have witnessed a resurgence in interest in CD4 - CD8+, CD4 - CD8- (double negative [DN]), and CD4 + Foxp3- type 1 Treg (Tr1) Treg and their role in controlling autoimmune diseases and in promoting the survival of organ allografts and xenografts. CD8+ and DN Treg can arise spontaneously (natural Treg) or can be induced in situ. Both CD8+ and DN Treg have been shown to enhance the survival of organ allografts and xenografts. Additionally, both can suppress alloimmune responses by contact-dependent mechanisms by either inducing apoptosis or mediating direct cytolysis of effector T cells. CD8+, DN, and Tr1 Treg can also act in a contact-independent manner by elaborating soluble immunosuppressive factors, such as TGF-β and IL-10. Applying CD8+, DN, and Tr1 Treg for enhancing the survival of organ allografts and xenografts is still in its infancy but holds significant potential. Furthermore, there is a need for a more comprehensive understanding of how current immunosuppressive therapies applied to organ transplantations affect the wide array of Treg populations. | ||
| 650 | 4 | |a T-Lymphocytes, Regulatory - drug effects | |
| 650 | 4 | |a Graft Rejection - prevention & control | |
| 650 | 4 | |a CD8-Positive T-Lymphocytes - immunology | |
| 650 | 4 | |a Biological Markers - metabolism | |
| 650 | 4 | |a T-Lymphocytes, Regulatory - immunology | |
| 650 | 4 | |a T-Lymphocytes, Regulatory - metabolism | |
| 650 | 4 | |a Graft Rejection - immunology | |
| 650 | 4 | |a CD8-Positive T-Lymphocytes - metabolism | |
| 650 | 4 | |a Immunosuppressive Agents - therapeutic use | |
| 650 | 4 | |a Graft Rejection - metabolism | |
| 650 | 4 | |a Organ Transplantation - adverse effects | |
| 650 | 4 | |a CD8-Positive T-Lymphocytes - drug effects | |
| 650 | 4 | |a Graft Survival - drug effects | |
| 700 | 1 | |a Niederkorn, Jerry Y |4 oth | |
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