Type 2 diabetes mellitus is associated with altered CD8+ T and natural killer cell function in pulmonary tuberculosis
Type 2 diabetes mellitus ( DM ) is associated with expanded frequencies of mycobacterial antigen‐specific CD 4 + T helper type 1 (Th1) and Th17 cells in individuals with active pulmonary tuberculosis ( TB ). No data are available on the role of CD 8 + T and natural killer ( NK ) cells in TB with coincident DM . To identify the role of CD 8 + T and NK cells in pulmonary TB with diabetes, we examined mycobacteria‐specific immune responses in the whole blood of individuals with TB and DM ( TB ‐ DM ) and compared them with those without DM ( TB ‐ NDM ). We found that TB ‐ DM is characterized by elevated frequencies of mycobacterial antigen‐stimulated CD 8 + T cells expressing type 1 [interferon‐ γ and interleukin‐2 ( IL ‐2)] and type 17 ( IL ‐17F) cytokines. We also found that TB ‐ DM is characterized by expanded frequencies of TB antigen‐stimulated NK cells expressing type 1 (tumour necrosis factor‐ α ) and type 17 ( IL ‐17A and IL ‐17F) cytokines. In contrast, CD 8 + T cells were associated with significantly diminished expression of the cytotoxic markers perforin, granzyme B and CD 107a both at baseline and following antigen or anti‐ CD 3 stimulation, while NK cells were associated with significantly decreased antigen‐stimulated expression of CD 107a only. This was not associated with alterations in CD 8 + T‐cell or NK cell numbers or subset distribution. Therefore, our data suggest that pulmonary TB complicated with type 2 DM is associated with an altered repertoire of cytokine‐producing and cytotoxic molecule‐expressing CD 8 + T and NK cells, possibly contributing to increased pathology..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:144 |
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| Enthalten in: |
Immunology - 144(2015), 4, Seite 677-686 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kumar, Nathella P [VerfasserIn] |
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| Links: |
Volltext |
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| RVK: |
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| doi: |
10.1111/imm.12421 |
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| funding: |
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| 245 | 1 | 0 | |a Type 2 diabetes mellitus is associated with altered CD8+ T and natural killer cell function in pulmonary tuberculosis |
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| 520 | |a Type 2 diabetes mellitus ( DM ) is associated with expanded frequencies of mycobacterial antigen‐specific CD 4 + T helper type 1 (Th1) and Th17 cells in individuals with active pulmonary tuberculosis ( TB ). No data are available on the role of CD 8 + T and natural killer ( NK ) cells in TB with coincident DM . To identify the role of CD 8 + T and NK cells in pulmonary TB with diabetes, we examined mycobacteria‐specific immune responses in the whole blood of individuals with TB and DM ( TB ‐ DM ) and compared them with those without DM ( TB ‐ NDM ). We found that TB ‐ DM is characterized by elevated frequencies of mycobacterial antigen‐stimulated CD 8 + T cells expressing type 1 [interferon‐ γ and interleukin‐2 ( IL ‐2)] and type 17 ( IL ‐17F) cytokines. We also found that TB ‐ DM is characterized by expanded frequencies of TB antigen‐stimulated NK cells expressing type 1 (tumour necrosis factor‐ α ) and type 17 ( IL ‐17A and IL ‐17F) cytokines. In contrast, CD 8 + T cells were associated with significantly diminished expression of the cytotoxic markers perforin, granzyme B and CD 107a both at baseline and following antigen or anti‐ CD 3 stimulation, while NK cells were associated with significantly decreased antigen‐stimulated expression of CD 107a only. This was not associated with alterations in CD 8 + T‐cell or NK cell numbers or subset distribution. Therefore, our data suggest that pulmonary TB complicated with type 2 DM is associated with an altered repertoire of cytokine‐producing and cytotoxic molecule‐expressing CD 8 + T and NK cells, possibly contributing to increased pathology. | ||
| 540 | |a Nutzungsrecht: © Published 2014. This article is a U.S. Government work and is in the public domain in the USA. | ||
| 650 | 4 | |a tuberculosis | |
| 650 | 4 | |a natural killer cells | |
| 650 | 4 | |a diabetes | |
| 650 | 4 | |a T cells | |
| 650 | 4 | |a Diabetes Mellitus, Type 1 - complications | |
| 650 | 4 | |a Mycobacterium tuberculosis - pathogenicity | |
| 650 | 4 | |a CD8-Positive T-Lymphocytes - microbiology | |
| 650 | 4 | |a Tuberculosis, Pulmonary - blood | |
| 650 | 4 | |a CD8-Positive T-Lymphocytes - immunology | |
| 650 | 4 | |a Killer Cells, Natural - immunology | |
| 650 | 4 | |a Cytokines - immunology | |
| 650 | 4 | |a Killer Cells, Natural - microbiology | |
| 650 | 4 | |a Diabetes Mellitus, Type 1 - blood | |
| 650 | 4 | |a CD8-Positive T-Lymphocytes - metabolism | |
| 650 | 4 | |a Biological Markers - blood | |
| 650 | 4 | |a Mycobacterium tuberculosis - immunology | |
| 650 | 4 | |a Diabetes Mellitus, Type 1 - immunology | |
| 650 | 4 | |a Diabetes Mellitus, Type 1 - diagnosis | |
| 650 | 4 | |a Tuberculosis, Pulmonary - complications | |
| 650 | 4 | |a Antigens, Bacterial - immunology | |
| 650 | 4 | |a Tuberculosis, Pulmonary - immunology | |
| 650 | 4 | |a Killer Cells, Natural - metabolism | |
| 650 | 4 | |a Cytokines - blood | |
| 650 | 4 | |a Tuberculosis, Pulmonary - microbiology | |
| 650 | 4 | |a Tuberculosis, Pulmonary - diagnosis | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a Tuberculosis | |
| 650 | 4 | |a Cytotoxicity | |
| 650 | 4 | |a Antigens | |
| 650 | 4 | |a Immune system | |
| 650 | 4 | |a Diabetes | |
| 700 | 1 | |a Sridhar, Rathinam |4 oth | |
| 700 | 1 | |a Nair, Dina |4 oth | |
| 700 | 1 | |a Banurekha, Vaithilingam V |4 oth | |
| 700 | 1 | |a Nutman, Thomas B |4 oth | |
| 700 | 1 | |a Babu, Subash |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Immunology |d Oxford [u.a.] : Wiley-Blackwell, 1958 |g 144(2015), 4, Seite 677-686 |w (DE-627)129269271 |w (DE-600)80124-0 |w (DE-576)01445971X |x 0019-2805 |7 nnns |
| 773 | 1 | 8 | |g volume:144 |g year:2015 |g number:4 |g pages:677-686 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1111/imm.12421 |3 Volltext |
| 856 | 4 | 2 | |u http://onlinelibrary.wiley.com/doi/10.1111/imm.12421/abstract |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/25363329 |
| 856 | 4 | 2 | |u http://search.proquest.com/docview/1661488498 |
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