Cross-immunity and age patterns of influenza A(H5N1) infection
The age distribution of influenza A(H5N1) cases reported during 2006-2013 varied substantially between countries. As well as underlying demographic profiles, it is possible that cross-immunity contributed to the age distribution of reported cases: seasonal influenza A(H1N1) and avian influenza A(H5N1) share the same neuraminidase subtype, N1. Using a mechanistic model, we measured the extent to which population age distribution and heterosubtypic cross-immunity could explain the observed age patterns in Cambodia, China, Egypt, Indonesia and Vietnam. Our results support experimental evidence that prior infection with H1N1 confers partial cross-immunity to H5N1, and suggest that more than 50% of spillover events did not lead to reported cases of infection as a result. We also identified age groups that have additional risk factors for influenza A(H5N1) not captured by demography or infection history..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:143 |
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| Enthalten in: |
Epidemiology and infection - 143(2015), 6, Seite 1119 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kucharski, A J [VerfasserIn] |
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| Links: |
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| RVK: |
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| doi: |
10.1017/S0950268814001976 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Cross-immunity and age patterns of influenza A(H5N1) infection |
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| 520 | |a The age distribution of influenza A(H5N1) cases reported during 2006-2013 varied substantially between countries. As well as underlying demographic profiles, it is possible that cross-immunity contributed to the age distribution of reported cases: seasonal influenza A(H1N1) and avian influenza A(H5N1) share the same neuraminidase subtype, N1. Using a mechanistic model, we measured the extent to which population age distribution and heterosubtypic cross-immunity could explain the observed age patterns in Cambodia, China, Egypt, Indonesia and Vietnam. Our results support experimental evidence that prior infection with H1N1 confers partial cross-immunity to H5N1, and suggest that more than 50% of spillover events did not lead to reported cases of infection as a result. We also identified age groups that have additional risk factors for influenza A(H5N1) not captured by demography or infection history. | ||
| 650 | 4 | |a Influenza, Human - epidemiology | |
| 650 | 4 | |a Influenza, Human - virology | |
| 650 | 4 | |a Influenza A Virus, H1N1 Subtype - immunology | |
| 650 | 4 | |a Influenza A Virus, H5N1 Subtype - immunology | |
| 650 | 4 | |a Cross Reactions - immunology | |
| 650 | 4 | |a Influenza, Human - immunology | |
| 650 | 4 | |a emerging infections | |
| 650 | 4 | |a mathematical modelling | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a Avian flu | |
| 650 | 4 | |a influenza A | |
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