Increasing inflationary T‐cell responses following transient depletion of MCMV‐specific memory T cells
Murine CMV (MCMV) infection induces effector CD8 + T cells that continue to increase in frequency after acute infection (“inflation”) and are stably maintained at a high frequency, with up to 20% of the CD8 + T‐cell compartment being specific for one epitope, although the flexibility and turnover of these populations is not fully defined. Here we report that effector/memory CD8 + T cells induced by MCMV can be paradoxically boosted following transient depletion of epitope specific CD8 + T cells. Treatment of MCMV‐infected mice with MHC‐Class I‐saporin tetramers led to partial (80–90%) depletion of epitope‐specific CD8 + T cells—rapidly followed by a rebound, leading to expansion and maintenance of up to 40% of total CD8 + T cells, with minimal changes in response to a control epitope (M45). These data indicate the tight balance between host and virus during persistent infection and the functional flexibility of the “inflated” CD8 + T cell responses during persistent infection..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
European journal of immunology - 45(2015), 1, Seite 113-118 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sims, Stuart [VerfasserIn] |
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| Links: |
Volltext |
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| doi: |
10.1002/eji.201445016 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC1962968022 |
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| 245 | 1 | 0 | |a Increasing inflationary T‐cell responses following transient depletion of MCMV‐specific memory T cells |
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| 520 | |a Murine CMV (MCMV) infection induces effector CD8 + T cells that continue to increase in frequency after acute infection (“inflation”) and are stably maintained at a high frequency, with up to 20% of the CD8 + T‐cell compartment being specific for one epitope, although the flexibility and turnover of these populations is not fully defined. Here we report that effector/memory CD8 + T cells induced by MCMV can be paradoxically boosted following transient depletion of epitope specific CD8 + T cells. Treatment of MCMV‐infected mice with MHC‐Class I‐saporin tetramers led to partial (80–90%) depletion of epitope‐specific CD8 + T cells—rapidly followed by a rebound, leading to expansion and maintenance of up to 40% of total CD8 + T cells, with minimal changes in response to a control epitope (M45). These data indicate the tight balance between host and virus during persistent infection and the functional flexibility of the “inflated” CD8 + T cell responses during persistent infection. | ||
| 540 | |a Nutzungsrecht: © 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim | ||
| 540 | |a © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | ||
| 540 | |a © 2015 The Authors. published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 2015 | ||
| 650 | 4 | |a MCMV | |
| 650 | 4 | |a Memory T cells | |
| 650 | 4 | |a Inflationary T‐cell response | |
| 650 | 4 | |a Histocompatibility Antigens Class I - immunology | |
| 650 | 4 | |a CD8-Positive T-Lymphocytes - immunology | |
| 650 | 4 | |a Saponins - chemistry | |
| 650 | 4 | |a CD8-Positive T-Lymphocytes - pathology | |
| 650 | 4 | |a Histocompatibility Antigens Class I - chemistry | |
| 650 | 4 | |a Herpesviridae Infections - pathology | |
| 650 | 4 | |a Muromegalovirus - immunology | |
| 650 | 4 | |a Herpesviridae Infections - immunology | |
| 650 | 4 | |a Herpesviridae Infections - virology | |
| 650 | 4 | |a CD8-Positive T-Lymphocytes - virology | |
| 650 | 4 | |a Epitopes, T-Lymphocyte - immunology | |
| 650 | 4 | |a Histocompatibility Antigens Class I - administration & dosage | |
| 650 | 4 | |a CD8-Positive T-Lymphocytes - drug effects | |
| 650 | 4 | |a Epitopes, T-Lymphocyte - chemistry | |
| 650 | 4 | |a Immunodominant Epitopes - chemistry | |
| 650 | 4 | |a Lymphocytes | |
| 650 | 4 | |a Infections | |
| 650 | 4 | |a Inflationary T-cell response | |
| 650 | 4 | |a Immunity to Infection | |
| 700 | 1 | |a Klenerman, Paul |4 oth | |
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| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/25331015 |
| 856 | 4 | 2 | |u http://search.proquest.com/docview/1644579991 |
| 856 | 4 | 2 | |u http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4477908&tool=pmcentrez&rendertype=abstract |
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