Increased risk of Bell palsy in patients with migraine: A nationwide cohort study
OBJECTIVE:To evaluate the association between migraine and Bell palsy and to examine the effects of age, sex, migraine subtype, and comorbid risk factors for Bell palsy. METHODS:This nationwide cohort study was conducted using data from the Taiwan National Health Insurance Research Database. Subjects aged 18 years or older with neurologist-diagnosed migraine from 2005 to 2009 were included. A nonheadache age- and propensity score–matched control cohort was selected for comparison. All subjects were followed until the end of 2010, death, or the occurrence of a Bell palsy event. Cox proportional hazards regression was used to calculate the adjusted hazard ratios and 95% confidence intervals to compare the risk of Bell palsy between groups. RESULTS:Both cohorts (n = 136,704 each) were followed for a mean of 3.2 years. During the follow-up period, 671 patients (424,372 person-years) in the migraine cohort and 365 matched control subjects (438,677 person-years) were newly diagnosed with Bell palsy (incidence rates, 158.1 and 83.2/100,000 person-years, respectively). The adjusted hazard ratio for Bell palsy was 1.91 (95% confidence interval, 1.68–2.17; p < 0.001). The association between migraine and Bell palsy remained significant in sensitivity analyses, and tests of interaction failed to reach significance in all subgroup analyses. CONCLUSION:Migraine is a previously unidentified risk factor for Bell palsy. The association between these 2 conditions suggests a linked disease mechanism, which is worthy of further exploration..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:84 |
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| Enthalten in: |
Neurology - 84(2015), 2, Seite 116-124 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Peng, Kuan-Po [VerfasserIn] |
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| Links: |
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| RVK: |
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| doi: |
10.1212/WNL.0000000000001124 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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OLC1962460681 |
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| 245 | 1 | 0 | |a Increased risk of Bell palsy in patients with migraine: A nationwide cohort study |
| 264 | 1 | |c 2015 | |
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| 520 | |a OBJECTIVE:To evaluate the association between migraine and Bell palsy and to examine the effects of age, sex, migraine subtype, and comorbid risk factors for Bell palsy. METHODS:This nationwide cohort study was conducted using data from the Taiwan National Health Insurance Research Database. Subjects aged 18 years or older with neurologist-diagnosed migraine from 2005 to 2009 were included. A nonheadache age- and propensity score–matched control cohort was selected for comparison. All subjects were followed until the end of 2010, death, or the occurrence of a Bell palsy event. Cox proportional hazards regression was used to calculate the adjusted hazard ratios and 95% confidence intervals to compare the risk of Bell palsy between groups. RESULTS:Both cohorts (n = 136,704 each) were followed for a mean of 3.2 years. During the follow-up period, 671 patients (424,372 person-years) in the migraine cohort and 365 matched control subjects (438,677 person-years) were newly diagnosed with Bell palsy (incidence rates, 158.1 and 83.2/100,000 person-years, respectively). The adjusted hazard ratio for Bell palsy was 1.91 (95% confidence interval, 1.68–2.17; p < 0.001). The association between migraine and Bell palsy remained significant in sensitivity analyses, and tests of interaction failed to reach significance in all subgroup analyses. CONCLUSION:Migraine is a previously unidentified risk factor for Bell palsy. The association between these 2 conditions suggests a linked disease mechanism, which is worthy of further exploration. | ||
| 540 | |a Nutzungsrecht: © 2015 American Academy of Neurology | ||
| 540 | |a © 2014 American Academy of Neurology. | ||
| 650 | 4 | |a Migraine Disorders - complications | |
| 650 | 4 | |a Bell Palsy - etiology | |
| 650 | 4 | |a Migraine without Aura - epidemiology | |
| 650 | 4 | |a Migraine with Aura - epidemiology | |
| 650 | 4 | |a Migraine with Aura - complications | |
| 650 | 4 | |a Bell Palsy - epidemiology | |
| 650 | 4 | |a Migraine without Aura - complications | |
| 650 | 4 | |a Migraine Disorders - epidemiology | |
| 700 | 1 | |a Chen, Yung-Tai |4 oth | |
| 700 | 1 | |a Fuh, Jong-Ling |4 oth | |
| 700 | 1 | |a Tang, Chao-Hsiun |4 oth | |
| 700 | 1 | |a Wang, Shuu-Jiun |4 oth | |
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