Liquid Chromatographic, Spectrophotometric and Potentiometric pK a Determination of Ranitidine and Famotidine
The dissociation constant (pK a ) is one of the most significant properties of a substance chemical moiety which has to be estimated with accuracy. Liquid chromatographic, spectrophotometric and potentiometric methods are often employed for determination of pK a values of compounds. This study describes the practice of these three methods to the determination of dissociation constant values of famotidine and ranitidine in acetonitrile-water binary mixtures. From these constants, aqueous dissociation constants of investigated substances were calculated by different approaches. Moreover, estimation of aqueous pK a values ( w w pK a ) can also be predicted by computational method (Marvin Sketch) on the basis of molecular structure. Results obtained from w w pK a values are compared with Marvin Sketch program and literature values..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Current drug therapy - 9(2015), 4, Seite 277-284 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Y. Dogan Daldal [VerfasserIn] |
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| 520 | |a The dissociation constant (pK a ) is one of the most significant properties of a substance chemical moiety which has to be estimated with accuracy. Liquid chromatographic, spectrophotometric and potentiometric methods are often employed for determination of pK a values of compounds. This study describes the practice of these three methods to the determination of dissociation constant values of famotidine and ranitidine in acetonitrile-water binary mixtures. From these constants, aqueous dissociation constants of investigated substances were calculated by different approaches. Moreover, estimation of aqueous pK a values ( w w pK a ) can also be predicted by computational method (Marvin Sketch) on the basis of molecular structure. Results obtained from w w pK a values are compared with Marvin Sketch program and literature values. | ||
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