A Kinase Divided
In this issue of Cancer Cell, Herrero and colleagues identify an anti-tumorigenic small molecule that blocks ERK dimerization, but neither its catalytic activity nor its phosphorylation by MEK. These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for inhibiting kinase signaling pathways associated with lower drug resistance..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Cancer cell - 28(2015), 2, Seite 145-147 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Karra, Aroon S [VerfasserIn] |
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| Links: |
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| doi: |
10.1016/j.ccell.2015.07.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a In this issue of Cancer Cell, Herrero and colleagues identify an anti-tumorigenic small molecule that blocks ERK dimerization, but neither its catalytic activity nor its phosphorylation by MEK. These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for inhibiting kinase signaling pathways associated with lower drug resistance. | ||
| 540 | |a Nutzungsrecht: Copyright © 2015 Elsevier Inc. All rights reserved. | ||
| 540 | |a © COPYRIGHT 2015 Elsevier B.V. | ||
| 650 | 4 | |a ras Proteins - metabolism | |
| 650 | 4 | |a Signal Transduction - drug effects | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | |
| 650 | 4 | |a Protein Multimerization - drug effects | |
| 650 | 4 | |a Carcinogenesis - drug effects | |
| 650 | 4 | |a Small Molecule Libraries - pharmacology | |
| 700 | 1 | |a Taylor, 4th, Clinton A |4 oth | |
| 700 | 1 | |a Thorne, Curtis A |4 oth | |
| 700 | 1 | |a Cobb, Melanie H |4 oth | |
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| 856 | 4 | 1 | |u http://dx.doi.org/10.1016/j.ccell.2015.07.008 |3 Volltext |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/26267529 |
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