Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome
The synthesis, SAR, and in vivo activity of inhibitors of delta-5 desaturase are described. Ring-constraint of the initial series provided access to a variety of in vitro active chemotypes, from which the indazole was selected. Examples from the indazole series displayed in vivo activity in reducing the enzymatic activity of liver delta-5 desaturase..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Bioorganic & medicinal chemistry letters - 25(2015), 18, Seite 3836-3839 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Baugh, Simon D P [VerfasserIn] |
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| Links: |
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| RVK: |
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| doi: |
10.1016/j.bmcl.2015.07.066 |
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| funding: |
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OLC1959110918 |
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| 520 | |a The synthesis, SAR, and in vivo activity of inhibitors of delta-5 desaturase are described. Ring-constraint of the initial series provided access to a variety of in vitro active chemotypes, from which the indazole was selected. Examples from the indazole series displayed in vivo activity in reducing the enzymatic activity of liver delta-5 desaturase. | ||
| 540 | |a Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. | ||
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| 700 | 1 | |a Gopinathan, Suma |4 oth | |
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| 700 | 1 | |a Hari, Rajee |4 oth | |
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| 700 | 1 | |a Smith, Arian |4 oth | |
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