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|a B-Cells induce regulatory T cells through TGF-β/IDO production in A CTLA-4 dependent manner
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|c 2015
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|a Text
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|a A number of studies have suggested that B cell mediated-regulation contributes to the establishment of immunological tolerance. However, the precise mechanisms by which regulatory B cells establish and maintain tolerance in humans remain to be determined. The objective of the current study is to understand the cellular and molecular bases of B-cell regulatory functions in humans. To describe the mechanisms regulating the functional plasticity of regulatory B cells, we used an in vitro co-culture model based on autologous mixed lymphocyte cultures involving freshly isolated B and T cells. The results show that activated B cells regulate T cell proliferation through producing transforming growth factor (TGF)-β and indoleamine 2,3-dioxygenase (IDO). The production of TGF-β and IDO leads to the induction of not only "natural" regulatory T cells but also of TGF-β-producing CD4(+) T cells and IL-10-producing regulatory T cells. Furthermore, we evidenced for the first time that CTLA-4 induces B-cells to produce IDO and to become effective induced regulatory B cells (iBregs). This study emphasizes a novel regulatory axis and open news insights in how to manage regulatory B cell functions in autoimmunity.
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|a Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved.
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|a Pochard, P
|4 oth
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|a Simon, Q
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|a Ségalen, I
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|a Le Meur, Y
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|a Pers, J O
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|a Hillion, S
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|i Enthalten in
|t Journal of autoimmunity
|d Amsterdam : Elsevier, 1988
|g 59(2015), Seite 53
|w (DE-627)165660295
|w (DE-600)639452-8
|w (DE-576)022914277
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|g volume:59
|g year:2015
|g pages:53
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|u http://www.ncbi.nlm.nih.gov/pubmed/25753821
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