Microglial content-dependent inhibitory effects of calcitonin gene-related peptide (CGRP) on murine retroviral infection of glial cells
C57BL/6 (B6) mice develop peripheral neuropathy post-LP-BM5 infection, a murine model of HIV-1 infection, along with the up-regulation of select spinal cord cytokines. We investigated if calcitonin gene-related peptide (CGRP) contributed to the development of peripheral neuropathy by stimulating glial responses. An increased expression of lumbar spinal cord CGRP was observed in vivo, post-LP-BM5 infection. Consequently, in vitro CGRP co-treatments led to a microglial content-dependent attenuation of viral loads in spinal cord mixed glia infected with selected doses of LP-BM5. This inhibition was neither caused by the loss of glia nor induced via the direct inhibition of LP-BM5 by CGRP..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:279 |
|---|---|
| Enthalten in: |
Journal of neuroimmunology - 279(2015), Seite 64-70 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Malon, Jennifer T [VerfasserIn] |
|---|
| Links: |
|---|
| RVK: |
|---|
| doi: |
10.1016/j.jneuroim.2015.01.010 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC1956647678 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1956647678 | ||
| 003 | DE-627 | ||
| 005 | 20230517063642.0 | ||
| 007 | tu | ||
| 008 | 160206s2015 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jneuroim.2015.01.010 |2 doi | |
| 028 | 5 | 2 | |a PQ20160617 |
| 035 | |a (DE-627)OLC1956647678 | ||
| 035 | |a (DE-599)GBVOLC1956647678 | ||
| 035 | |a (PRQ)c1301-d53b513f707834574c5e76b4ba9beefd1e4101d43ed851aba1d167c74af8c9a0 | ||
| 035 | |a (KEY)0125030220150000279000000064microglialcontentdependentinhibitoryeffectsofcalci | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q DNB |
| 084 | |a XA 10000 |q AVZ |2 rvk | ||
| 084 | |a 44.90 |2 bkl | ||
| 084 | |a 44.45 |2 bkl | ||
| 100 | 1 | |a Malon, Jennifer T |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Microglial content-dependent inhibitory effects of calcitonin gene-related peptide (CGRP) on murine retroviral infection of glial cells |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a C57BL/6 (B6) mice develop peripheral neuropathy post-LP-BM5 infection, a murine model of HIV-1 infection, along with the up-regulation of select spinal cord cytokines. We investigated if calcitonin gene-related peptide (CGRP) contributed to the development of peripheral neuropathy by stimulating glial responses. An increased expression of lumbar spinal cord CGRP was observed in vivo, post-LP-BM5 infection. Consequently, in vitro CGRP co-treatments led to a microglial content-dependent attenuation of viral loads in spinal cord mixed glia infected with selected doses of LP-BM5. This inhibition was neither caused by the loss of glia nor induced via the direct inhibition of LP-BM5 by CGRP. | ||
| 540 | |a Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. | ||
| 650 | 4 | |a Calcitonin Gene-Related Peptide - metabolism | |
| 650 | 4 | |a Spinal Cord - pathology | |
| 650 | 4 | |a Neuroglia - metabolism | |
| 650 | 4 | |a Retroviridae Infections - pathology | |
| 650 | 4 | |a Gene Expression Regulation - drug effects | |
| 650 | 4 | |a Retroviridae - pathogenicity | |
| 650 | 4 | |a Cytokines - genetics | |
| 650 | 4 | |a Up-Regulation - physiology | |
| 650 | 4 | |a Gene Expression Regulation - physiology | |
| 650 | 4 | |a Calcitonin Gene-Related Peptide - pharmacology | |
| 650 | 4 | |a Cytokines - metabolism | |
| 700 | 1 | |a Grlickova-Duzevik, Eliza |4 oth | |
| 700 | 1 | |a Vaughn, James |4 oth | |
| 700 | 1 | |a Beaulac, Holly |4 oth | |
| 700 | 1 | |a Vunk, Tyler R |4 oth | |
| 700 | 1 | |a Cao, Ling |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neuroimmunology |d Amsterdam : Elsevier, 1981 |g 279(2015), Seite 64-70 |w (DE-627)129098442 |w (DE-600)8335-5 |w (DE-576)014435233 |x 0165-5728 |7 nnns |
| 773 | 1 | 8 | |g volume:279 |g year:2015 |g pages:64-70 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1016/j.jneuroim.2015.01.010 |3 Volltext |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/25670002 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4219 | ||
| 936 | r | v | |a XA 10000 |
| 936 | b | k | |a 44.90 |q AVZ |
| 936 | b | k | |a 44.45 |q AVZ |
| 951 | |a AR | ||
| 952 | |d 279 |j 2015 |h 64-70 | ||