B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis
The protective role of B cells and humoral immune responses in tuberculosis infection has been regarded as inferior to cellular immunity directed to the intracellular pathogen Mycobacterium tuberculosis. However, B-cell-mediated immune responses in tuberculosis have recently been revisited in the context of B-cell physiology and antigen presentation. We discuss in this review the diverse functions of B cells in tuberculosis, with a focus on their biological and clinical relevance to progression of active disease. We also present the peptide microarray platform as a promising strategy to discover unknown antigenic targets of M. tuberculosis that could contribute to the better understanding of epitope focus of the humoral immune system against M. tuberculosis..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61Suppl 3 |
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| Enthalten in: |
Clinical infectious diseases - 61Suppl 3(2015), suppl 3, Seite S225-S234 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rao, Martin [VerfasserIn] |
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| Links: |
Volltext |
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| Themen: |
A Blueprint for Opportunities |
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| doi: |
10.1093/cid/civ614 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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OLC1956632735 |
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| 520 | |a The protective role of B cells and humoral immune responses in tuberculosis infection has been regarded as inferior to cellular immunity directed to the intracellular pathogen Mycobacterium tuberculosis. However, B-cell-mediated immune responses in tuberculosis have recently been revisited in the context of B-cell physiology and antigen presentation. We discuss in this review the diverse functions of B cells in tuberculosis, with a focus on their biological and clinical relevance to progression of active disease. We also present the peptide microarray platform as a promising strategy to discover unknown antigenic targets of M. tuberculosis that could contribute to the better understanding of epitope focus of the humoral immune system against M. tuberculosis. | ||
| 540 | |a Nutzungsrecht: © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. | ||
| 540 | |a © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. 2015 | ||
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