Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens
We compared a lateral flow immunoassay (LFA) to a currently used enzyme immunoassay for detection of cryptococcal antigen in 396 sera and 651 cerebrospinal fluid specimens. We found 97% concordance between the 2 assays. The LFA detected an additional 22 positives. Overall, the LFA had sensitivity of 100% and specificity of 99.6% for the diagnosis of cryptococcosis. The LFA is rapid, accurate, and easy to perform, and it is suitable for routine patient care testing..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:82 |
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| Enthalten in: |
Diagnostic microbiology and infectious disease - 82(2015), 1, Seite 54 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Suwantarat, Nuntra [VerfasserIn] |
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| Links: |
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| doi: |
10.1016/j.diagmicrobio.2015.01.012 |
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| funding: |
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| PPN (Katalog-ID): |
OLC1956558187 |
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| 245 | 1 | 0 | |a Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens |
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| 520 | |a We compared a lateral flow immunoassay (LFA) to a currently used enzyme immunoassay for detection of cryptococcal antigen in 396 sera and 651 cerebrospinal fluid specimens. We found 97% concordance between the 2 assays. The LFA detected an additional 22 positives. Overall, the LFA had sensitivity of 100% and specificity of 99.6% for the diagnosis of cryptococcosis. The LFA is rapid, accurate, and easy to perform, and it is suitable for routine patient care testing. | ||
| 540 | |a Nutzungsrecht: Copyright © 2015 Elsevier Inc. All rights reserved. | ||
| 650 | 4 | |a Antigens, Fungal - cerebrospinal fluid | |
| 650 | 4 | |a Serum - chemistry | |
| 650 | 4 | |a Immunoenzyme Techniques - methods | |
| 650 | 4 | |a Cryptococcosis - diagnosis | |
| 650 | 4 | |a Cerebrospinal Fluid - chemistry | |
| 650 | 4 | |a Diagnostic Tests, Routine - methods | |
| 650 | 4 | |a Antigens, Fungal - blood | |
| 650 | 4 | |a Immunochromatography - methods | |
| 700 | 1 | |a Dalton, Justin B |4 oth | |
| 700 | 1 | |a Lee, Richard |4 oth | |
| 700 | 1 | |a Green, Rachel |4 oth | |
| 700 | 1 | |a Memon, Warda |4 oth | |
| 700 | 1 | |a Carroll, Karen C |4 oth | |
| 700 | 1 | |a Riedel, Stefan |4 oth | |
| 700 | 1 | |a Zhang, Sean X |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Diagnostic microbiology and infectious disease |d New York, NY : Elsevier, 1983 |g 82(2015), 1, Seite 54 |w (DE-627)130399507 |w (DE-600)604920-5 |w (DE-576)025082213 |x 0732-8893 |7 nnns |
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| 856 | 4 | 1 | |u http://dx.doi.org/10.1016/j.diagmicrobio.2015.01.012 |3 Volltext |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/25698631 |
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