Analysis of new-onset seizures following use of COVID-19 vaccinations in children based on VAERS
BACKGROUND: Recently, there have been some reports of seizures related with COVID-19 vaccinations. However, no studies have systematically investigated the relationship between seizures and various COVID-19 vaccines.
RESEARCH DESIGN AND METHODS: This research aimed to analyze the characteristics and risk signals of new-onset seizures in children caused by various COVID-19 vaccines based on the data of the Vaccine Adverse Event Reporting System (VAERS). To identify potential risk signals, a disproportionality analysis was conducted. The reporting odds ratio (ROR) and the Proportional Reporting Ratio (PRR) were used to detect signals.
RESULTS: A total of 695 children with new-onset seizures events associated with COVID-19 vaccinations were retrieved from the VAERS database. Compared with influenza vaccinations, the percentage and rate of COVID-19 vaccinations related seizures was all reduced. The median onset time of seizures was 1 day after COVID-19 vaccines. No signal was detected for an association between the COVID-19 vaccines and new-onset seizures, neither when compared with influenza vaccines nor with non-COVID-19 vaccines.
CONCLUSION: No statistically significant risk signal of COVID-19 vaccine-related seizures was found in this study. However, it is still necessary to monitor the possibility of new-onset seizures when children are immunized with COVID-19 vaccines.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Expert opinion on drug safety - (2024) vom: 01. Mai, Seite 1-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Yanhui [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 02.05.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1080/14740338.2024.2348568 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM371551420 |
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| 245 | 1 | 0 | |a Analysis of new-onset seizures following use of COVID-19 vaccinations in children based on VAERS |
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| 500 | |a Date Revised 02.05.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a BACKGROUND: Recently, there have been some reports of seizures related with COVID-19 vaccinations. However, no studies have systematically investigated the relationship between seizures and various COVID-19 vaccines | ||
| 520 | |a RESEARCH DESIGN AND METHODS: This research aimed to analyze the characteristics and risk signals of new-onset seizures in children caused by various COVID-19 vaccines based on the data of the Vaccine Adverse Event Reporting System (VAERS). To identify potential risk signals, a disproportionality analysis was conducted. The reporting odds ratio (ROR) and the Proportional Reporting Ratio (PRR) were used to detect signals | ||
| 520 | |a RESULTS: A total of 695 children with new-onset seizures events associated with COVID-19 vaccinations were retrieved from the VAERS database. Compared with influenza vaccinations, the percentage and rate of COVID-19 vaccinations related seizures was all reduced. The median onset time of seizures was 1 day after COVID-19 vaccines. No signal was detected for an association between the COVID-19 vaccines and new-onset seizures, neither when compared with influenza vaccines nor with non-COVID-19 vaccines | ||
| 520 | |a CONCLUSION: No statistically significant risk signal of COVID-19 vaccine-related seizures was found in this study. However, it is still necessary to monitor the possibility of new-onset seizures when children are immunized with COVID-19 vaccines | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a AEs | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a VAERS data | |
| 650 | 4 | |a seizures | |
| 650 | 4 | |a vaccination | |
| 700 | 1 | |a He, Jinyang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Xiaozhu |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Heping |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Yuquan |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Xiangli |e verfasserin |4 aut | |
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