Tenascin-C targeting strategies in cancer
Copyright © 2024. Published by Elsevier B.V..
Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Matrix biology : journal of the International Society for Matrix Biology - (2024) vom: 18. Apr. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Dhaouadi, Sayda [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antibody |
|---|
| Anmerkungen: |
Date Revised 20.04.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1016/j.matbio.2024.04.002 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM371318025 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM371318025 | ||
| 003 | DE-627 | ||
| 005 | 20240421232235.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240421s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.matbio.2024.04.002 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1382.xml |
| 035 | |a (DE-627)NLM371318025 | ||
| 035 | |a (NLM)38642843 | ||
| 035 | |a (PII)S0945-053X(24)00052-0 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Dhaouadi, Sayda |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Tenascin-C targeting strategies in cancer |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 20.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024. Published by Elsevier B.V. | ||
| 520 | |a Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Tenascin-C | |
| 650 | 4 | |a antibody | |
| 650 | 4 | |a aptamer | |
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a cancer | |
| 650 | 4 | |a diagnostic application | |
| 650 | 4 | |a extracellular matrix | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a nanobody | |
| 650 | 4 | |a peptide | |
| 650 | 4 | |a therapeutic approach | |
| 650 | 4 | |a tumor | |
| 650 | 4 | |a tumor immunity | |
| 700 | 1 | |a Bouhaouala-Zahar, Balkiss |e verfasserin |4 aut | |
| 700 | 1 | |a Orend, Gertraud |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Matrix biology : journal of the International Society for Matrix Biology |d 1996 |g (2024) vom: 18. Apr. |w (DE-627)NLM074964305 |x 1569-1802 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:18 |g month:04 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.matbio.2024.04.002 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 18 |c 04 | ||