Genetic Susceptibility Variants of Vascular Dementia among Asians : A Systematic Review and Meta-Analysis
S. Karger AG, Basel..
INTRODUCTION: Vascular dementia (VaD), a neurocognitive impairment directly related to vascular injury, is the second most common cause of age-related dementia. Although numerous studies have investigated candidate genetic polymorphisms associated with VaD in Asia, the genetics of VaD remains unclear.
METHODS: This review provides an updated meta-analysis of genetic polymorphisms associated with VaD in Asians, using the PRISMA guidelines. Published literature up to May 2021 was extracted from the PubMed, Scopus, Ovid, and EBSCO host databases. Meta-analysis was conducted using the Open Meta analyst, Review Manager, and MedCalc® Statistical Software. Trial sequential analysis (TSA) was performed using TSA viewer software.
RESULTS: A total of 46 eligible studies, comprising 23 genes and 35 SNPs, were retrieved. The meta-analysis was conducted on the following genetic polymorphisms, APOE ε2/3/4, MTHFR rs1801131, ACE rs4340 (I/D) gene polymorphism, and a PSEN1 intron 8 variant. The pooled ORs revealed a significant increase in the risk of VaD in the Apolipoprotein E (APOE) ε4 allelic model: OR, 1.79, p<0.001), and the methylenetetrahydrofolate reductase (MTHFR) rs1801133 polymorphism T allele in the allelic model (OR, 1.23, p=0.013).
CONCLUSION: Our findings provide evidence that genetic polymorphisms of the APOE ε4 allele and MTHFR rs1801133 T allele increase the risk of developing VaD in Asians. However, future large-scale investigations examining particularly on South-Eastern and West-Asian populations are highly recommended.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
---|---|
Enthalten in: |
Dementia and geriatric cognitive disorders - (2024) vom: 18. Apr. |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Ramachandran, Vasudevan [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Revised 18.04.2024 published: Print-Electronic Citation Status Publisher |
---|
doi: |
10.1159/000538864 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM371254531 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM371254531 | ||
003 | DE-627 | ||
005 | 20240419233214.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240419s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1159/000538864 |2 doi | |
028 | 5 | 2 | |a pubmed24n1380.xml |
035 | |a (DE-627)NLM371254531 | ||
035 | |a (NLM)38636474 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Ramachandran, Vasudevan |e verfasserin |4 aut | |
245 | 1 | 0 | |a Genetic Susceptibility Variants of Vascular Dementia among Asians |b A Systematic Review and Meta-Analysis |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 18.04.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status Publisher | ||
520 | |a S. Karger AG, Basel. | ||
520 | |a INTRODUCTION: Vascular dementia (VaD), a neurocognitive impairment directly related to vascular injury, is the second most common cause of age-related dementia. Although numerous studies have investigated candidate genetic polymorphisms associated with VaD in Asia, the genetics of VaD remains unclear | ||
520 | |a METHODS: This review provides an updated meta-analysis of genetic polymorphisms associated with VaD in Asians, using the PRISMA guidelines. Published literature up to May 2021 was extracted from the PubMed, Scopus, Ovid, and EBSCO host databases. Meta-analysis was conducted using the Open Meta analyst, Review Manager, and MedCalc® Statistical Software. Trial sequential analysis (TSA) was performed using TSA viewer software | ||
520 | |a RESULTS: A total of 46 eligible studies, comprising 23 genes and 35 SNPs, were retrieved. The meta-analysis was conducted on the following genetic polymorphisms, APOE ε2/3/4, MTHFR rs1801131, ACE rs4340 (I/D) gene polymorphism, and a PSEN1 intron 8 variant. The pooled ORs revealed a significant increase in the risk of VaD in the Apolipoprotein E (APOE) ε4 allelic model: OR, 1.79, p<0.001), and the methylenetetrahydrofolate reductase (MTHFR) rs1801133 polymorphism T allele in the allelic model (OR, 1.23, p=0.013) | ||
520 | |a CONCLUSION: Our findings provide evidence that genetic polymorphisms of the APOE ε4 allele and MTHFR rs1801133 T allele increase the risk of developing VaD in Asians. However, future large-scale investigations examining particularly on South-Eastern and West-Asian populations are highly recommended | ||
650 | 4 | |a Systematic Review | |
700 | 1 | |a Mohamad, Nur Afiqah |e verfasserin |4 aut | |
700 | 1 | |a Salleh, Mohd Nazil |e verfasserin |4 aut | |
700 | 1 | |a Wan Sulaiman, Wan Aliaa |e verfasserin |4 aut | |
700 | 1 | |a Inche Mat, Liyana Najwa |e verfasserin |4 aut | |
700 | 1 | |a Mohamed, Mohd Hazmi |e verfasserin |4 aut | |
700 | 1 | |a Siew Mooi, Ching |e verfasserin |4 aut | |
700 | 1 | |a Yusof Khan, Abdul Hanif Khan |e verfasserin |4 aut | |
700 | 1 | |a Basri, Hamidon |e verfasserin |4 aut | |
700 | 1 | |a Periasamy, Pannerselvam |e verfasserin |4 aut | |
700 | 1 | |a Suganthi, Vajiravelu |e verfasserin |4 aut | |
700 | 1 | |a Jayaraman, Narenkumar |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Dementia and geriatric cognitive disorders |d 1998 |g (2024) vom: 18. Apr. |w (DE-627)NLM089633423 |x 1421-9824 |7 nnns |
773 | 1 | 8 | |g year:2024 |g day:18 |g month:04 |
856 | 4 | 0 | |u http://dx.doi.org/10.1159/000538864 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |j 2024 |b 18 |c 04 |