A Structure-Activity Investigation of the Fungal Metabolite (-)-TAN-2483B : Inhibition of Bruton's tyrosine kinase
© 2024 Wiley‐VCH GmbH..
The natural product (-)-TAN-2483B is a fungal secondary metabolite which displays promising anti-cancer and immunomodulatory activity. Our previous syntheses of (-)-TAN-2483B and sidechain analogues uncovered inhibitory activity against Bruton's tyrosine kinase (Btk), an established drug target for various leukaemia and immunological diseases. A structure-based computational study using ensemble docking and molecular dynamics was performed to determine plausible binding modes for (-)-TAN-2483B and analogues in the Btk binding site. These hypotheses guided the design of new analogues which were synthesised and their inhibitory activities determined, providing insights into the structural determinants of the furopyranone scaffold that confer both activity and selectivity for Btk. These findings offer new perspectives for generating optimised (-)-TAN-2483B-based kinase inhibitors for the treatment of leukaemia and immunological diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Chemistry (Weinheim an der Bergstrasse, Germany) - (2024) vom: 17. Apr., Seite e202401051 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
McCone, Jordan [VerfasserIn] |
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| Links: |
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| Themen: |
Docking |
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| Anmerkungen: |
Date Revised 17.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1002/chem.202401051 |
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| funding: |
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| PPN (Katalog-ID): |
NLM371187648 |
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| 245 | 1 | 2 | |a A Structure-Activity Investigation of the Fungal Metabolite (-)-TAN-2483B |b Inhibition of Bruton's tyrosine kinase |
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| 520 | |a © 2024 Wiley‐VCH GmbH. | ||
| 520 | |a The natural product (-)-TAN-2483B is a fungal secondary metabolite which displays promising anti-cancer and immunomodulatory activity. Our previous syntheses of (-)-TAN-2483B and sidechain analogues uncovered inhibitory activity against Bruton's tyrosine kinase (Btk), an established drug target for various leukaemia and immunological diseases. A structure-based computational study using ensemble docking and molecular dynamics was performed to determine plausible binding modes for (-)-TAN-2483B and analogues in the Btk binding site. These hypotheses guided the design of new analogues which were synthesised and their inhibitory activities determined, providing insights into the structural determinants of the furopyranone scaffold that confer both activity and selectivity for Btk. These findings offer new perspectives for generating optimised (-)-TAN-2483B-based kinase inhibitors for the treatment of leukaemia and immunological diseases | ||
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| 700 | 1 | |a Flanagan, Jack U |e verfasserin |4 aut | |
| 700 | 1 | |a Harvey, Joanne E |e verfasserin |4 aut | |
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