Prognostic effect of masked morning hypertension in Chinese inpatients with non-dialysis chronic kidney disease : A multi-center retrospective study
© The Author(s) 2024. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd..
OBJECTIVE: This study aimed to elucidate the prognostic role of Masked Morning Hypertension (MMH) in non-dialysis-dependent chronic kidney disease (NDD-CKD).
METHODS: 2,130 NDD-CKD patients of inpatient department were categorized into four blood pressure groups: clinical normotension (CH-), clinical hypertension (CH+) with morning hypertension (MH+), and without MH+ (MH-) respectively. The correlation between these four blood pressure types and the primary (all-cause mortality) and secondary endpoints (cardio-cerebrovascular disease [CVD] and end-stage kidney disease [ESKD]) was analyzed.
RESULTS: The prevalences of morning hypertension and masked morning hypertension were 47.4% and 14.98%, respectively. Morning hypertension independently increased the risk of all-cause mortality (P=0.004) and CVD (P<0.001) but not ESKD (P=0.092). Masked morning hypertension was associated with heightened all-cause mortality (HR = 4.22, 95% CI = 1.31-13.59; P=0.02) and CVD events (HR = 5.14, 95% CI = 1.37-19.23; P=0.02), with no significant association with ESKD (HR = 1.18, 95% CI = 0.65-2.15; P=0.60). When considering non-CVD deaths as a competing risk factor, a high cumulative incidence of CVD events was observed in the masked morning hypertension group (HR = 5.16, 95% CI = 1.39-19.08).
CONCLUSIONS: MMH is an independent risk factor for all-cause mortality and combined cardiovascular and cerebrovascular events in NDD-CKD patients, underscoring its prognostic significance. This highlights the need for comprehensive management of morning hypertension in this population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
American journal of hypertension - (2024) vom: 16. Apr. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lin, Lin [VerfasserIn] |
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| Links: |
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| Themen: |
All-cause mortality |
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| Anmerkungen: |
Date Revised 16.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1093/ajh/hpae044 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM37114826X |
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| 100 | 1 | |a Lin, Lin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic effect of masked morning hypertension in Chinese inpatients with non-dialysis chronic kidney disease |b A multi-center retrospective study |
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| 500 | |a Citation Status Publisher | ||
| 520 | |a © The Author(s) 2024. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. | ||
| 520 | |a OBJECTIVE: This study aimed to elucidate the prognostic role of Masked Morning Hypertension (MMH) in non-dialysis-dependent chronic kidney disease (NDD-CKD) | ||
| 520 | |a METHODS: 2,130 NDD-CKD patients of inpatient department were categorized into four blood pressure groups: clinical normotension (CH-), clinical hypertension (CH+) with morning hypertension (MH+), and without MH+ (MH-) respectively. The correlation between these four blood pressure types and the primary (all-cause mortality) and secondary endpoints (cardio-cerebrovascular disease [CVD] and end-stage kidney disease [ESKD]) was analyzed | ||
| 520 | |a RESULTS: The prevalences of morning hypertension and masked morning hypertension were 47.4% and 14.98%, respectively. Morning hypertension independently increased the risk of all-cause mortality (P=0.004) and CVD (P<0.001) but not ESKD (P=0.092). Masked morning hypertension was associated with heightened all-cause mortality (HR = 4.22, 95% CI = 1.31-13.59; P=0.02) and CVD events (HR = 5.14, 95% CI = 1.37-19.23; P=0.02), with no significant association with ESKD (HR = 1.18, 95% CI = 0.65-2.15; P=0.60). When considering non-CVD deaths as a competing risk factor, a high cumulative incidence of CVD events was observed in the masked morning hypertension group (HR = 5.16, 95% CI = 1.39-19.08) | ||
| 520 | |a CONCLUSIONS: MMH is an independent risk factor for all-cause mortality and combined cardiovascular and cerebrovascular events in NDD-CKD patients, underscoring its prognostic significance. This highlights the need for comprehensive management of morning hypertension in this population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a all-cause mortality | |
| 650 | 4 | |a cardio-cerebrovascular disease | |
| 650 | 4 | |a chronic kidney disease | |
| 650 | 4 | |a end-stage kidney disease | |
| 650 | 4 | |a masked morning hypertension | |
| 700 | 1 | |a Jiang, Xinying |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Lingling |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Jingcan |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Tiantian |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Yuting |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Man |e verfasserin |4 aut | |
| 700 | 1 | |a Peng, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Cheng |e verfasserin |4 aut | |
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