Anthocyanins from blueberry ameliorated arsenic-induced memory impairment, oxidative stress, and mitochondrial-biosynthesis imbalance in rat hippocampal neurons
Copyright © 2024 Elsevier Inc. All rights reserved..
In this study, blueberry anthocyanins extract (BAE) was used to investigate its protective effect on arsenic-induced rat hippocampal neurons damage. Arsenic exposure resulted in elevated levels of oxidative stress, decreased antioxidant capacity and increased apoptosis in rat hippocampal brain tissue and mitochondria. Immunohistochemical results showed that arsenic exposure also significantly decreased the expression of mitochondrial biosynthesis-related factors PGC-1α and TFAM. Treatment with BAE alleviated the decrease in antioxidant capacity, mitochondrial biogenesis related protein PGC-1α/NRF2/TFAM expression, and ATP production of arsenic induced hippocampal neurons in rats, and improved cognitive function in arsenic damaged rats. This study provides new insights into the detoxification effect of anthocyanins on the nervous system toxicity caused by metal exposure in the environment, indicating that anthocyanins may be a natural antioxidant against the nervous system toxicity caused by environmental metal exposure.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:119 |
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| Enthalten in: |
Cellular signalling - 119(2024) vom: 15. Apr., Seite 111177 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ma, Xinbo [VerfasserIn] |
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| Links: |
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| Themen: |
Anthocyanins |
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| Anmerkungen: |
Date Revised 16.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.cellsig.2024.111177 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM371105919 |
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| 520 | |a In this study, blueberry anthocyanins extract (BAE) was used to investigate its protective effect on arsenic-induced rat hippocampal neurons damage. Arsenic exposure resulted in elevated levels of oxidative stress, decreased antioxidant capacity and increased apoptosis in rat hippocampal brain tissue and mitochondria. Immunohistochemical results showed that arsenic exposure also significantly decreased the expression of mitochondrial biosynthesis-related factors PGC-1α and TFAM. Treatment with BAE alleviated the decrease in antioxidant capacity, mitochondrial biogenesis related protein PGC-1α/NRF2/TFAM expression, and ATP production of arsenic induced hippocampal neurons in rats, and improved cognitive function in arsenic damaged rats. This study provides new insights into the detoxification effect of anthocyanins on the nervous system toxicity caused by metal exposure in the environment, indicating that anthocyanins may be a natural antioxidant against the nervous system toxicity caused by environmental metal exposure | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anthocyanins | |
| 650 | 4 | |a Arsenic | |
| 650 | 4 | |a Mitochondrial biosynthesis | |
| 700 | 1 | |a Liu, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Siqi |e verfasserin |4 aut | |
| 700 | 1 | |a Ni, Bangyao |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yuting |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Liu |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yanan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yuchen |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yuxi |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yanmei |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiaona |e verfasserin |4 aut | |
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