circRNAs as prognostic markers in pediatric acute myeloid leukemia
Copyright © 2024 Elsevier B.V. All rights reserved..
Circular RNAs (circRNAs) arise from precursor mRNA processing through back-splicing and have been increasingly recognized for their functions in various cancers including acute myeloid leukemia (AML). However, the prognostic implications of circRNA in AML remain unclear. We conducted a comprehensive genome-wide analysis of circRNAs using RNA-seq data in pediatric AML. We revealed a group of circRNAs associated with inferior outcomes, exerting effects on cancer-related pathways. Several of these circRNAs were transcribed directly from genes with established functions in AML, such as circRUNX1, circWHSC1, and circFLT3. Further investigations indicated the increased number of circRNAs and linear RNAs splicing were significantly correlated with inferior clinical outcomes, highlighting the pivotal role of splicing dysregulation. Subsequent analysis identified a group of upregulated RNA binding proteins in AMLs associated with high number of circRNAs, with TROVE2 being a prominent candidate, suggesting their involvement in circRNA associated prognosis. Through the integration of drug sensitivity data, we pinpointed 25 drugs that could target high-risk AMLs characterized by aberrant circRNA transcription. These findings underscore prognostic significance of circRNAs in pediatric AML and offer an alternative perspective for treating high-risk cases in this malignancy.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:591 |
|---|---|
| Enthalten in: |
Cancer letters - 591(2024) vom: 15. Apr., Seite 216880 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sun, Huiying [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Circular RNA |
|---|
| Anmerkungen: |
Date Revised 19.04.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1016/j.canlet.2024.216880 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM371105854 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM371105854 | ||
| 003 | DE-627 | ||
| 005 | 20240420232458.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240416s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.canlet.2024.216880 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1381.xml |
| 035 | |a (DE-627)NLM371105854 | ||
| 035 | |a (NLM)38621457 | ||
| 035 | |a (PII)S0304-3835(24)00273-8 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Sun, Huiying |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a circRNAs as prognostic markers in pediatric acute myeloid leukemia |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 19.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a Circular RNAs (circRNAs) arise from precursor mRNA processing through back-splicing and have been increasingly recognized for their functions in various cancers including acute myeloid leukemia (AML). However, the prognostic implications of circRNA in AML remain unclear. We conducted a comprehensive genome-wide analysis of circRNAs using RNA-seq data in pediatric AML. We revealed a group of circRNAs associated with inferior outcomes, exerting effects on cancer-related pathways. Several of these circRNAs were transcribed directly from genes with established functions in AML, such as circRUNX1, circWHSC1, and circFLT3. Further investigations indicated the increased number of circRNAs and linear RNAs splicing were significantly correlated with inferior clinical outcomes, highlighting the pivotal role of splicing dysregulation. Subsequent analysis identified a group of upregulated RNA binding proteins in AMLs associated with high number of circRNAs, with TROVE2 being a prominent candidate, suggesting their involvement in circRNA associated prognosis. Through the integration of drug sensitivity data, we pinpointed 25 drugs that could target high-risk AMLs characterized by aberrant circRNA transcription. These findings underscore prognostic significance of circRNAs in pediatric AML and offer an alternative perspective for treating high-risk cases in this malignancy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Circular RNA | |
| 650 | 4 | |a Pediatric acute myeloid leukemia | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a RNA binding proteins | |
| 650 | 4 | |a RNA splicing dysregulation | |
| 700 | 1 | |a Xie, Yangyang |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Xiaoyan |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Wenting |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xiaoxiao |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Kefei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Han |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Shuang |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Qiaoqiao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiang |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Bowen |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Wenyan |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Rongrong |e verfasserin |4 aut | |
| 700 | 1 | |a Rao, Jianan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ronghua |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Binbing S |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Shuhong |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yu |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer letters |d 1976 |g 591(2024) vom: 15. Apr., Seite 216880 |w (DE-627)NLM000147273 |x 1872-7980 |7 nnns |
| 773 | 1 | 8 | |g volume:591 |g year:2024 |g day:15 |g month:04 |g pages:216880 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.canlet.2024.216880 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 591 |j 2024 |b 15 |c 04 |h 216880 | ||