Highly sensitive lanthanide complex as a probe for l-kynurenine : A cancer biomarker
© 2024 John Wiley & Sons Ltd..
A lanthanide complex based on europium (Eu) and chelidamic acid was synthesized (Eu-CHE) and characterized. The complex Eu-CHE exhibited intense luminescence at 615 nm under excitation at 300 nm and was further investigated for highly sensitive turn-off detection of l-kynurenine (l-kyn), a cancer biomarker. The probe detected l-kyn linearly from 6 nM to 0.2 μM with a limit of detection and limit of quantification of 1.37 and 4.57 nM, respectively. The probe was investigated for selectivity towards l-kyn among co-existing amino acids and further extended for detecting l-kyn from human serum and urine samples. A low-cost paper strip-based sensing platform was also developed for the visual detection of l-kyn.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Luminescence : the journal of biological and chemical luminescence - 39(2024), 4 vom: 30. Apr., Seite e4740 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Varghese, Susan [VerfasserIn] |
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| Links: |
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| Themen: |
343-65-7 |
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| Anmerkungen: |
Date Completed 16.04.2024 Date Revised 16.04.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1002/bio.4740 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM371079950 |
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| 520 | |a A lanthanide complex based on europium (Eu) and chelidamic acid was synthesized (Eu-CHE) and characterized. The complex Eu-CHE exhibited intense luminescence at 615 nm under excitation at 300 nm and was further investigated for highly sensitive turn-off detection of l-kynurenine (l-kyn), a cancer biomarker. The probe detected l-kyn linearly from 6 nM to 0.2 μM with a limit of detection and limit of quantification of 1.37 and 4.57 nM, respectively. The probe was investigated for selectivity towards l-kyn among co-existing amino acids and further extended for detecting l-kyn from human serum and urine samples. A low-cost paper strip-based sensing platform was also developed for the visual detection of l-kyn | ||
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| 700 | 1 | |a Abraham, Merin K |e verfasserin |4 aut | |
| 700 | 1 | |a Shkhair, Ali Ibrahim |e verfasserin |4 aut | |
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| 700 | 1 | |a B K, Arathy |e verfasserin |4 aut | |
| 700 | 1 | |a George, Sony |e verfasserin |4 aut | |
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