Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia : insights from large-scale genome-wide cross-trait analysis

© 2024. The Author(s)..

BACKGROUND: To study the shared genetic structure between autoimmune diseases and B-cell acute lymphoblastic leukemia (B-ALL) and identify the shared risk loci and genes and genetic mechanisms involved.

METHODS: Based on large-scale genome-wide association study (GWAS) summary-level data sets, we observed genetic overlaps between autoimmune diseases and B-ALL, and cross-trait pleiotropic analysis was performed to detect shared pleiotropic loci and genes. A series of functional annotation and tissue-specific analysis were performed to determine the influence of pleiotropic genes. The heritability enrichment analysis was used to detect crucial immune cells and tissues. Finally, bidirectional Mendelian randomization (MR) methods were utilized to investigate the casual associations.

RESULTS: Our research highlighted shared genetic mechanisms between seven autoimmune disorders and B-ALL. A total of 73 pleiotropic loci were identified at the genome-wide significance level (P < 5 × 10-8), 16 of which had strong evidence of colocalization. We demonstrated that several loci have been previously reported (e.g., 17q21) and discovered some novel loci (e.g., 10p12, 5p13). Further gene-level identified 194 unique pleiotropic genes, for example IKZF1, GATA3, IKZF3, GSDMB, and ORMDL3. Pathway analysis determined the key role of cellular response to cytokine stimulus, B cell activation, and JAK-STAT signaling pathways. SNP-level and gene-level tissue enrichment suggested that crucial role pleiotropic mechanisms involved in the spleen, whole blood, and EBV-transformed lymphocytes. Also, hyprcoloc and stratified LD score regression analyses revealed that B cells at different developmental stages may be involved in mechanisms shared between two different diseases. Finally, two-sample MR analysis determined causal effects of asthma and rheumatoid arthritis on B-ALL.

CONCLUSIONS: Our research proved shared genetic architecture between autoimmune disorders and B-ALL and shed light on the potential mechanism that might involve in.

Medienart:

E-Artikel

Erscheinungsjahr:

2024

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - volume:22

Enthalten in:

BMC medicine - 22(2024), 1 vom: 15. Apr., Seite 161

Sprache:

Englisch

Beteiligte Personen:

Yu, Xinghao [VerfasserIn]
Chen, Yiyin [VerfasserIn]
Chen, Jia [VerfasserIn]
Fan, Yi [VerfasserIn]
Lu, Huimin [VerfasserIn]
Wu, Depei [VerfasserIn]
Xu, Yang [VerfasserIn]

Links:

Volltext

Themen:

Autoimmune disease
B-cell acute lymphoblastic leukemia
Genetic overlap
Journal Article
Mendelian randomization

Anmerkungen:

Date Completed 16.04.2024

Date Revised 25.04.2024

published: Electronic

Citation Status MEDLINE

doi:

10.1186/s12916-024-03385-0

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM371055768