Dendritic polymer prodrug-based unimolecular micelles for pH-responsive co-delivery of doxorubicin and camptothecin with synergistic controlled drug release effect
Copyright © 2024 Elsevier B.V. All rights reserved..
Combination chemotherapy has been recognized as a more powerful strategy for tumor treatment rather than the single chemotherapy. However, the interactive mechanism of the two hydrophobic chemotherapeutic drugs has not been explored by now. Aiming for a better synergistic effect, such interactive mechanism was investigated in the present work, by designing CPTDOX-DPUTEA-PEG nanomedicine with encapsulated camptothecin (CPT) and conjugated doxorubicin (DOX). The synergistic controlled drug release effect was found for the two drugs loaded on the different sites of the dendritic polyurethane core. Synergism was achieved on the HepG2 cells with a combination index (CI) of 0.58 in the in vitro cellular experiments. The results demonstrated the promising application of the unimolecular micelles-based nanomedicine with independently loading of two hydrophobic chemotherapeutic drugs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:238 |
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| Enthalten in: |
Colloids and surfaces. B, Biointerfaces - 238(2024) vom: 11. Apr., Seite 113906 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
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| Links: |
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| Themen: |
Combination chemotherapy |
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| Anmerkungen: |
Date Revised 14.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.colsurfb.2024.113906 |
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| funding: |
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| 500 | |a published: Print-Electronic | ||
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| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a Combination chemotherapy has been recognized as a more powerful strategy for tumor treatment rather than the single chemotherapy. However, the interactive mechanism of the two hydrophobic chemotherapeutic drugs has not been explored by now. Aiming for a better synergistic effect, such interactive mechanism was investigated in the present work, by designing CPTDOX-DPUTEA-PEG nanomedicine with encapsulated camptothecin (CPT) and conjugated doxorubicin (DOX). The synergistic controlled drug release effect was found for the two drugs loaded on the different sites of the dendritic polyurethane core. Synergism was achieved on the HepG2 cells with a combination index (CI) of 0.58 in the in vitro cellular experiments. The results demonstrated the promising application of the unimolecular micelles-based nanomedicine with independently loading of two hydrophobic chemotherapeutic drugs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Combination chemotherapy | |
| 650 | 4 | |a Dendritic polymer prodrug | |
| 650 | 4 | |a Drug co-delivery system | |
| 650 | 4 | |a Unimolecular micelles | |
| 650 | 4 | |a pH-Responsive drug release | |
| 700 | 1 | |a Liu, Peng |e verfasserin |4 aut | |
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