Adherence to the ultra-processed dietary pattern and risk of depressive outcomes : Findings from the NutriNet Brasil cohort study and an updated systematic review and meta-analysis
Copyright © 2024 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved..
BACKGROUND & AIMS: We aimed to analyze the prospective association between adherence to the ultra-processed dietary pattern and risk of depressive outcomes using original data from the NutriNet Brasil cohort and via a systematic review and meta-analysis of observational studies that have investigated the same association.
METHODS: In our original research analysis, we used data from 15,960 adults (≥18 y) participating in the NutriNet Brasil cohort study, free of depression or depressive symptoms during the baseline (77.5% women, 45.8 ± 13.0 y). The mean dietary share of ultra-processed foods (%Kcal/d), calculated from two baseline 24-h dietary recalls, was used to measure the adherence to the ultra-processed dietary pattern. New cases of depressive symptoms were assessed using the Patient Health Questionnaire-9 over the follow-up period (mean: 18.3 months). Cox proportional hazards models were used for the main analyses. In our systematic review and meta-analysis, we incorporated effect estimates from six prospective cohort studies that have examined the same association, including ours.
RESULTS: In the adjusted model, each 10% increase in the dietary share of ultra-processed foods was associated with a 10% increase in the hazard of incident cases of depressive symptoms (HR:1.10; 95%CI: 1.07-1.14). This association was slightly attenuated in the models including potential mediators. In our meta-analysis of six prospective studies, high versus low exposure to ultra-processed foods was associated with a summary hazard ratio of depressive outcomes of 1.32; 95%CI: 1.19-1.46; I2: 71%.
CONCLUSION: A higher adherence to the ultra-processed dietary pattern was associated with a higher risk of developing depressive outcomes in the NutriNet Brasil cohort and in the meta-analysis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Clinical nutrition (Edinburgh, Scotland) - 43(2024), 5 vom: 01. Apr., Seite 1190-1199 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Werneck, André O [VerfasserIn] |
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| Links: |
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| Themen: |
Food processing |
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| Anmerkungen: |
Date Revised 13.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.clnu.2024.03.028 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Werneck, André O |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Adherence to the ultra-processed dietary pattern and risk of depressive outcomes |b Findings from the NutriNet Brasil cohort study and an updated systematic review and meta-analysis |
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| 500 | |a Date Revised 13.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. | ||
| 520 | |a BACKGROUND & AIMS: We aimed to analyze the prospective association between adherence to the ultra-processed dietary pattern and risk of depressive outcomes using original data from the NutriNet Brasil cohort and via a systematic review and meta-analysis of observational studies that have investigated the same association | ||
| 520 | |a METHODS: In our original research analysis, we used data from 15,960 adults (≥18 y) participating in the NutriNet Brasil cohort study, free of depression or depressive symptoms during the baseline (77.5% women, 45.8 ± 13.0 y). The mean dietary share of ultra-processed foods (%Kcal/d), calculated from two baseline 24-h dietary recalls, was used to measure the adherence to the ultra-processed dietary pattern. New cases of depressive symptoms were assessed using the Patient Health Questionnaire-9 over the follow-up period (mean: 18.3 months). Cox proportional hazards models were used for the main analyses. In our systematic review and meta-analysis, we incorporated effect estimates from six prospective cohort studies that have examined the same association, including ours | ||
| 520 | |a RESULTS: In the adjusted model, each 10% increase in the dietary share of ultra-processed foods was associated with a 10% increase in the hazard of incident cases of depressive symptoms (HR:1.10; 95%CI: 1.07-1.14). This association was slightly attenuated in the models including potential mediators. In our meta-analysis of six prospective studies, high versus low exposure to ultra-processed foods was associated with a summary hazard ratio of depressive outcomes of 1.32; 95%CI: 1.19-1.46; I2: 71% | ||
| 520 | |a CONCLUSION: A higher adherence to the ultra-processed dietary pattern was associated with a higher risk of developing depressive outcomes in the NutriNet Brasil cohort and in the meta-analysis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Food processing | |
| 650 | 4 | |a Major depressive disorder | |
| 650 | 4 | |a Mental health | |
| 650 | 4 | |a Nova food classification system | |
| 650 | 4 | |a Nutritional psychiatry | |
| 700 | 1 | |a Steele, Euridice M |e verfasserin |4 aut | |
| 700 | 1 | |a Delpino, Felipe M |e verfasserin |4 aut | |
| 700 | 1 | |a Lane, Melissa M |e verfasserin |4 aut | |
| 700 | 1 | |a Marx, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Jacka, Felice N |e verfasserin |4 aut | |
| 700 | 1 | |a Stubbs, Brendon |e verfasserin |4 aut | |
| 700 | 1 | |a Touvier, Mathilde |e verfasserin |4 aut | |
| 700 | 1 | |a Srour, Bernard |e verfasserin |4 aut | |
| 700 | 1 | |a Louzada, Maria Lc |e verfasserin |4 aut | |
| 700 | 1 | |a Levy, Renata B |e verfasserin |4 aut | |
| 700 | 1 | |a Monteiro, Carlos A |e verfasserin |4 aut | |
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