Effects of vitamin D3, omega-3 s and a simple strength training exercise program on bone health : the DO-HEALTH randomized controlled trial
© The Author(s) [2024]. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research..
INTRODUCTION: Evidence on the effects of Vitamin D, omega-3 s and exercise on aBMD in healthy older adults is limited. We examined whether vitamin D3, omega-3 s, or a simple home-based exercise program (SHEP), alone or in combination, over three years, improve lumbar spine (LS), femoral neck (FN) or total hip (TH) aBMD assessed by DXA.
METHODS: aBMD was a secondary outcome in DO-HEALTH, a 3-year, multicenter, double-blind, randomized 2 × 2 × 2 factorial design trial in generally healthy older adults age ≥ 70 years. The study interventions were vitamin D3 (2000IU/d), omega-3 s (1 g/d), and SHEP (3 × 30 min/wk), applied alone or in combination in 8 treatment arms. Mixed effect models were used adjusting for age, sex, BMI, prior fall, study site and baseline level of the outcome. Main effects were assessed in the absence of an interaction between the interventions. Subgroup analyses by sex, physical activity level, dietary calcium intake, serum 25(OH)D levels, and fracture history were conducted.
RESULTS: DXA scans were available for 1493 participants (mean age 75 years; 80.4% were physically active, 44% had 25(OH)D levels <20 ng/ml). At the LS and FN sites, none of the treatments showed a benefit. At the TH, vitamin D vs. no vitamin D treatment showed a significant benefit across 3 years (difference in adjusted means [AM]: 0.0035 [95% CI 0.0011, 0.0059] g/cm2). Furthermore, there was a benefit for vitamin D vs. no vitamin D treatment on LS aBMD in the male subgroup of (interaction P = 0.003; ∆AM: 0.0070 [95% CI 0.0007, 0.0132] g/cm2).
CONCLUSIONS: Omega-3 and SHEP had no benefit on aBMD in healthy, active and largely vitamin D replete older adults. Our study suggests a small benefit of 2000 IU vitamin D daily on TH aBMD overall and LS aBMD among men, however, effect sizes were very modest and the clinical impact of these findings is unclear.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - (2024) vom: 13. Apr. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Melanie, Kistler-Fischbacher [VerfasserIn] |
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| Anmerkungen: |
Date Revised 13.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1093/jbmr/zjae054 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM371027616 |
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| 245 | 1 | 0 | |a Effects of vitamin D3, omega-3 s and a simple strength training exercise program on bone health |b the DO-HEALTH randomized controlled trial |
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| 500 | |a Date Revised 13.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © The Author(s) [2024]. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. | ||
| 520 | |a INTRODUCTION: Evidence on the effects of Vitamin D, omega-3 s and exercise on aBMD in healthy older adults is limited. We examined whether vitamin D3, omega-3 s, or a simple home-based exercise program (SHEP), alone or in combination, over three years, improve lumbar spine (LS), femoral neck (FN) or total hip (TH) aBMD assessed by DXA | ||
| 520 | |a METHODS: aBMD was a secondary outcome in DO-HEALTH, a 3-year, multicenter, double-blind, randomized 2 × 2 × 2 factorial design trial in generally healthy older adults age ≥ 70 years. The study interventions were vitamin D3 (2000IU/d), omega-3 s (1 g/d), and SHEP (3 × 30 min/wk), applied alone or in combination in 8 treatment arms. Mixed effect models were used adjusting for age, sex, BMI, prior fall, study site and baseline level of the outcome. Main effects were assessed in the absence of an interaction between the interventions. Subgroup analyses by sex, physical activity level, dietary calcium intake, serum 25(OH)D levels, and fracture history were conducted | ||
| 520 | |a RESULTS: DXA scans were available for 1493 participants (mean age 75 years; 80.4% were physically active, 44% had 25(OH)D levels <20 ng/ml). At the LS and FN sites, none of the treatments showed a benefit. At the TH, vitamin D vs. no vitamin D treatment showed a significant benefit across 3 years (difference in adjusted means [AM]: 0.0035 [95% CI 0.0011, 0.0059] g/cm2). Furthermore, there was a benefit for vitamin D vs. no vitamin D treatment on LS aBMD in the male subgroup of (interaction P = 0.003; ∆AM: 0.0070 [95% CI 0.0007, 0.0132] g/cm2) | ||
| 520 | |a CONCLUSIONS: Omega-3 and SHEP had no benefit on aBMD in healthy, active and largely vitamin D replete older adults. Our study suggests a small benefit of 2000 IU vitamin D daily on TH aBMD overall and LS aBMD among men, however, effect sizes were very modest and the clinical impact of these findings is unclear | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Aging | |
| 650 | 4 | |a DXA | |
| 650 | 4 | |a Exercise | |
| 650 | 4 | |a Nutrition | |
| 650 | 4 | |a Osteoporosis | |
| 700 | 1 | |a Gabriele, Armbrecht |e verfasserin |4 aut | |
| 700 | 1 | |a Stephanie, Gängler |e verfasserin |4 aut | |
| 700 | 1 | |a Robert, Theiler |e verfasserin |4 aut | |
| 700 | 1 | |a Renè, Rizzoli |e verfasserin |4 aut | |
| 700 | 1 | |a Bess, Dawson-Hughes |e verfasserin |4 aut | |
| 700 | 1 | |a Kanis John, A |e verfasserin |4 aut | |
| 700 | 1 | |a Hofbauer Lorenz, C |e verfasserin |4 aut | |
| 700 | 1 | |a Schimmer Ralph, C |e verfasserin |4 aut | |
| 700 | 1 | |a Bruno, Vellas |e verfasserin |4 aut | |
| 700 | 1 | |a Da Silva José, A P |e verfasserin |4 aut | |
| 700 | 1 | |a John, Orav E |e verfasserin |4 aut | |
| 700 | 1 | |a Kressig Reto, W |e verfasserin |4 aut | |
| 700 | 1 | |a Andreas, Egli |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Lang |e verfasserin |4 aut | |
| 700 | 1 | |a Wanner Guido, A |e verfasserin |4 aut | |
| 700 | 1 | |a Bischoff-Ferrari Heike, A |e verfasserin |4 aut | |
| 700 | 0 | |a DO-HEALTH Research Group |e verfasserin |4 aut | |
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