Establishment of the HPLC fluorescence detection method for plasma trace ivermectin and its pharmacokinetics in Bactrian camel
© 2024 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd..
BACKGROUND AND OBJECTIVE: Ivermectin (IVM), a widely used veterinary anthelmintic, lacks recommended doses for Bactrian camels. This study aims to establish its pharmacokinetics in Bactrian camels, comparing with other livestock.
METHODS: A method for high-performance liquid chromatography fluorescence detection of IVM in plasma was developed.
RESULTS: IVM exhibited linear scaling (y = 0.6946x + 0.0088, R2 = 0.9988) within 0.025-5 ng/mL, with a lower limit of quantification of 25.00 pg/mL, high recovery (>70%) and low RSD (<7%). In Bactrian camels, IVM injection showed a low Cmax, extended Tmax and apparent secondary absorption compared to cattle and sheep.
CONCLUSIONS: Slow absorption and widespread distribution were observed, with peak concentration and area under the curve correlating positively with the dose. This study provides insights into IVM pharmacokinetics in Bactrian camels, informing dose determination and highlighting potential metabolic differences compared to other livestock.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Veterinary medicine and science - 10(2024), 3 vom: 08. Apr., Seite e1447 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hou, Bin [VerfasserIn] |
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| Links: |
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| Themen: |
70288-86-7 |
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| Anmerkungen: |
Date Completed 15.04.2024 Date Revised 25.04.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1002/vms3.1447 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM371024854 |
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| 245 | 1 | 0 | |a Establishment of the HPLC fluorescence detection method for plasma trace ivermectin and its pharmacokinetics in Bactrian camel |
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| 500 | |a Date Revised 25.04.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND AND OBJECTIVE: Ivermectin (IVM), a widely used veterinary anthelmintic, lacks recommended doses for Bactrian camels. This study aims to establish its pharmacokinetics in Bactrian camels, comparing with other livestock | ||
| 520 | |a METHODS: A method for high-performance liquid chromatography fluorescence detection of IVM in plasma was developed | ||
| 520 | |a RESULTS: IVM exhibited linear scaling (y = 0.6946x + 0.0088, R2 = 0.9988) within 0.025-5 ng/mL, with a lower limit of quantification of 25.00 pg/mL, high recovery (>70%) and low RSD (<7%). In Bactrian camels, IVM injection showed a low Cmax, extended Tmax and apparent secondary absorption compared to cattle and sheep | ||
| 520 | |a CONCLUSIONS: Slow absorption and widespread distribution were observed, with peak concentration and area under the curve correlating positively with the dose. This study provides insights into IVM pharmacokinetics in Bactrian camels, informing dose determination and highlighting potential metabolic differences compared to other livestock | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bactrian camel | |
| 650 | 4 | |a HPLC fluorescence detection | |
| 650 | 4 | |a ivermectin injection | |
| 650 | 4 | |a pharmacokinetic characteristics | |
| 650 | 7 | |a Ivermectin |2 NLM | |
| 650 | 7 | |a 70288-86-7 |2 NLM | |
| 700 | 1 | |a Wang, Haifeng |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Haosi, Bilige |e verfasserin |4 aut | |
| 700 | 1 | |a Hasi, Surong |e verfasserin |4 aut | |
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