SSTR2 Mediates the Inhibitory Effect of SST/CST on Lipolysis in Chicken Adipose Tissue
Somatostatin shows an anti-lipolytic effect in both chickens and ducks. However, its molecular mediator remains to be identified. Here, we report that somatostatin type 2 receptor (SSTR2) is expressed at a high level in chicken adipose tissue. In cultured chicken adipose tissue, the inhibition of glucagon-stimulated lipolysis by somatostatin was blocked by an SSTR2 antagonist (CYN-154086), supporting an SSTR2-mediated anti-lipolytic effect. Furthermore, a significant pro-proliferative effect was detected in SST28-treated immortalized chicken preadipocytes (ICP-1), and this cell proliferative effect may be mediated through the MAPK/ERK signaling pathway activated by SSTR2. In summary, our results demonstrate that SSTR2 may regulate adipose tissue development by affecting the number and volume of adipocytes in chickens.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Animals : an open access journal from MDPI - 14(2024), 7 vom: 28. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Xiao [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 25.04.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/ani14071034 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM371015820 |
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| 520 | |a Somatostatin shows an anti-lipolytic effect in both chickens and ducks. However, its molecular mediator remains to be identified. Here, we report that somatostatin type 2 receptor (SSTR2) is expressed at a high level in chicken adipose tissue. In cultured chicken adipose tissue, the inhibition of glucagon-stimulated lipolysis by somatostatin was blocked by an SSTR2 antagonist (CYN-154086), supporting an SSTR2-mediated anti-lipolytic effect. Furthermore, a significant pro-proliferative effect was detected in SST28-treated immortalized chicken preadipocytes (ICP-1), and this cell proliferative effect may be mediated through the MAPK/ERK signaling pathway activated by SSTR2. In summary, our results demonstrate that SSTR2 may regulate adipose tissue development by affecting the number and volume of adipocytes in chickens | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a SSTR2 | |
| 650 | 4 | |a adipose tissue | |
| 650 | 4 | |a chicken | |
| 650 | 4 | |a lipolysis | |
| 700 | 1 | |a Zhang, Jiannan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Tianjiao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xinglong |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Jiancheng |e verfasserin |4 aut | |
| 700 | 1 | |a He, Jiliang |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Ningkun |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yajun |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Juan |e verfasserin |4 aut | |
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