Exosomal miR-1202 mediates Brodmann Area 44 functional connectivity changes in medication-free patients with major depressive disorder : An fMRI study
Copyright © 2024 Elsevier B.V. All rights reserved..
Previous large-sample postmortem study revealed that the expression of miR-1202 in brain tissues from Brodmann area 44 (BA44) was dysregulated in patients with major depressive disorder (MDDs). However, the specific in vivo neuropathological mechanism of miR-1202 as well as its interplay with BA44 circuits in the depressed brain are still unclear. Here, we performed a case-control study with imaging-genetic approach based on resting-state functional magnetic resonance imaging (MRI) data and miR-1202 quantification from 110 medication-free MDDs and 102 healthy controls. Serum-derived circulating exosomes that readily cross the blood-brain barrier were isolated to quantify miR-1202. For validation, repeated MR scans were performed after a six-week follow-up of antidepressant treatment on a cohort of MDDs. Voxelwise factorial analysis revealed two brain areas (including the striatal-thalamic region) in which the effect of depression on the functional connectivity with BA44 was significantly dependent on the expression level of exosomal miR-1202. Moreover, longitudinal change of the BA44 connectivity with the striatal-thalamic region in MDDs after antidepressant treatment was found to be significantly related to the level of miR-1202 expression. These findings revealed that the in vivo neuropathological effect of miR-1202 dysregulation in depression is possibly exerted by mediating neural functional abnormalities in BA44-striatal-thalamic circuits.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:356 |
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| Enthalten in: |
Journal of affective disorders - 356(2024) vom: 10. Apr., Seite 470-476 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Han, Shuguang [VerfasserIn] |
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| Links: |
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| Themen: |
Functional connectivity |
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| Anmerkungen: |
Date Revised 23.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.jad.2024.04.042 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370980778 |
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| 100 | 1 | |a Han, Shuguang |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Exosomal miR-1202 mediates Brodmann Area 44 functional connectivity changes in medication-free patients with major depressive disorder |b An fMRI study |
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| 520 | |a Previous large-sample postmortem study revealed that the expression of miR-1202 in brain tissues from Brodmann area 44 (BA44) was dysregulated in patients with major depressive disorder (MDDs). However, the specific in vivo neuropathological mechanism of miR-1202 as well as its interplay with BA44 circuits in the depressed brain are still unclear. Here, we performed a case-control study with imaging-genetic approach based on resting-state functional magnetic resonance imaging (MRI) data and miR-1202 quantification from 110 medication-free MDDs and 102 healthy controls. Serum-derived circulating exosomes that readily cross the blood-brain barrier were isolated to quantify miR-1202. For validation, repeated MR scans were performed after a six-week follow-up of antidepressant treatment on a cohort of MDDs. Voxelwise factorial analysis revealed two brain areas (including the striatal-thalamic region) in which the effect of depression on the functional connectivity with BA44 was significantly dependent on the expression level of exosomal miR-1202. Moreover, longitudinal change of the BA44 connectivity with the striatal-thalamic region in MDDs after antidepressant treatment was found to be significantly related to the level of miR-1202 expression. These findings revealed that the in vivo neuropathological effect of miR-1202 dysregulation in depression is possibly exerted by mediating neural functional abnormalities in BA44-striatal-thalamic circuits | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Functional connectivity | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 650 | 4 | |a Major depressive disorder | |
| 650 | 4 | |a MicroRNA | |
| 700 | 1 | |a Zheng, Qingtong |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Zixuan |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiaohua |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Changzhou |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xuanxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Minghao |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Hou, Ziwei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Wen, Ge |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Yanjia |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Kai |e verfasserin |4 aut | |
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