Effect of EDTA with porous balloon on calcified lesion : An atherosclerotic cadaver study
© 2024 Wiley Periodicals LLC..
BACKGROUND: Ethylene diamine tetra-acetic acid (EDTA) is a chelating agent used to dissolve calcium deposits but evidence in decalcifying atherosclerotic lesions is limited.
AIMS: We assessed the feasibility and efficacy of EDTA delivered via porous balloon to target calcified lesions in cadaveric below-the-knee (BTK) arteries.
METHODS: Using porcine carotid arteries, EDTA concentration was measured in the arterial wall and outside the artery at the 0-, 0.5-, 4-, and 24-h circulation after the injection through a porous balloon. In cadaver BTK samples, the proximal and distal anterior tibial artery (ATA) and distal posterior tibial artery (PTA) were studied. EDTA-2Na/H2O or EDTA-3Na/H2O were administrated using a porous balloon, then circulated for 6 h for EDTA-3Na/H2O and 24 h for EDTA-2Na/H2O and EDTA-3Na/H2O. Micro-CT imaging of the artery segments before and after the circulation and cross-sectional analyses were performed to evaluate calcium burden.
RESULTS: In the porcine carotid study, EDTA was delivered through a porous balloon present in the arterial wall and was retained there for 24 h. In BTK arteries, cross-sectional analyses of micro-CT revealed a significant decrease in the calcium area in the distal ATA segment under 24-h circulation with EDTA-2Na/H2O and in the distal ATA segment under 24-h circulation with EDTA-3Na/H2O. The proximal ATA segment under 6-h circulation with EDTA-3Na/H2O showed no significant change in any parameters of calcium CONCLUSION: EDTA-3Na/H2O or EDTA-2Na/H2O with longer circulation times resulted in greater calcium reduction in atherosclerotic lesion. EDTA may have a potential therapeutic option for the treatment of atherosclerotic calcified lesions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:103 |
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| Enthalten in: |
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions - 103(2024), 6 vom: 25. Apr., Seite 972-981 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kawai, Kenji [VerfasserIn] |
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| Links: |
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| Themen: |
9G34HU7RV0 |
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| Anmerkungen: |
Date Completed 26.04.2024 Date Revised 26.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/ccd.31052 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Kawai, Kenji |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of EDTA with porous balloon on calcified lesion |b An atherosclerotic cadaver study |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024 Wiley Periodicals LLC. | ||
| 520 | |a BACKGROUND: Ethylene diamine tetra-acetic acid (EDTA) is a chelating agent used to dissolve calcium deposits but evidence in decalcifying atherosclerotic lesions is limited | ||
| 520 | |a AIMS: We assessed the feasibility and efficacy of EDTA delivered via porous balloon to target calcified lesions in cadaveric below-the-knee (BTK) arteries | ||
| 520 | |a METHODS: Using porcine carotid arteries, EDTA concentration was measured in the arterial wall and outside the artery at the 0-, 0.5-, 4-, and 24-h circulation after the injection through a porous balloon. In cadaver BTK samples, the proximal and distal anterior tibial artery (ATA) and distal posterior tibial artery (PTA) were studied. EDTA-2Na/H2O or EDTA-3Na/H2O were administrated using a porous balloon, then circulated for 6 h for EDTA-3Na/H2O and 24 h for EDTA-2Na/H2O and EDTA-3Na/H2O. Micro-CT imaging of the artery segments before and after the circulation and cross-sectional analyses were performed to evaluate calcium burden | ||
| 520 | |a RESULTS: In the porcine carotid study, EDTA was delivered through a porous balloon present in the arterial wall and was retained there for 24 h. In BTK arteries, cross-sectional analyses of micro-CT revealed a significant decrease in the calcium area in the distal ATA segment under 24-h circulation with EDTA-2Na/H2O and in the distal ATA segment under 24-h circulation with EDTA-3Na/H2O. The proximal ATA segment under 6-h circulation with EDTA-3Na/H2O showed no significant change in any parameters of calcium CONCLUSION: EDTA-3Na/H2O or EDTA-2Na/H2O with longer circulation times resulted in greater calcium reduction in atherosclerotic lesion. EDTA may have a potential therapeutic option for the treatment of atherosclerotic calcified lesions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a atherosclerosis | |
| 650 | 4 | |a below‐the‐knee | |
| 650 | 4 | |a calcification | |
| 650 | 4 | |a micro‐CT | |
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| 650 | 7 | |a Calcium Chelating Agents |2 NLM | |
| 700 | 1 | |a Madra, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Kawakami, Rika |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Konishi, Takao |e verfasserin |4 aut | |
| 700 | 1 | |a Shiraki, Tatsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Sekimoto, Teruo |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Takamasa |e verfasserin |4 aut | |
| 700 | 1 | |a Virmani, Renu |e verfasserin |4 aut | |
| 700 | 1 | |a Finn, Aloke V |e verfasserin |4 aut | |
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