Assessment of central nervous system vasculitis in children based on high-resolution vascular wall imaging
© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology..
Objectives: Central nervous system vasculitis (CNSV) is a rare disease. High-resolution vessel wall imaging (HR-VWI) enables the identification of inflammatory changes within the vessel wall. Few studies have applied HR-VWI to assess CNSV in children. This study delves into the utility of HR-VWI for diagnosing and treating CNSV in children, with the aim of enhancing clinical diagnosis and efficacy evaluation.
Methods: Imaging data were acquired from children who underwent HR-VWI examinations. The study meticulously analysed clinical data and laboratory tests to discern the characteristics and distribution patterns of diverse vasculitis forms.
Results: In children, CNSV mainly involves medium vessels with grade 1 and 2 stenosis (grade 4 stenosis is rare), and the imaging features generally show centripetal and moderate enhancement, suggesting that this feature is specific for the diagnosis of CNSV. High-grade stenosis, concentric enhancement and strong enhancement of the vasculature indicate more severe disease activity. Remarkably, HR-VWI proved to be significantly more sensitive than magnetic resonance angiography in detecting CNSV. Among the 13 cases subjected to imaging review, 8 demonstrated a reduction or resolution of vessel wall inflammation. In contrast, five patients exhibited worsening inflammation in the vessel wall. HR-VWI demonstrated that changes in vessel wall inflammation were closely correlated with changes in brain parenchymal lesions and symptoms.
Conclusion: This study underscores the diagnostic value of HR-VWI in CNSV assessment and treatment monitoring, offering a quantitative evaluation of CNSV in children.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Rheumatology advances in practice - 8(2024), 2 vom: 27., Seite rkae038 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cao, Yimin [VerfasserIn] |
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| Links: |
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| Themen: |
Central nervous system vasculitis |
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| Anmerkungen: |
Date Revised 25.04.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1093/rap/rkae038 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370950445 |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology. | ||
| 520 | |a Objectives: Central nervous system vasculitis (CNSV) is a rare disease. High-resolution vessel wall imaging (HR-VWI) enables the identification of inflammatory changes within the vessel wall. Few studies have applied HR-VWI to assess CNSV in children. This study delves into the utility of HR-VWI for diagnosing and treating CNSV in children, with the aim of enhancing clinical diagnosis and efficacy evaluation | ||
| 520 | |a Methods: Imaging data were acquired from children who underwent HR-VWI examinations. The study meticulously analysed clinical data and laboratory tests to discern the characteristics and distribution patterns of diverse vasculitis forms | ||
| 520 | |a Results: In children, CNSV mainly involves medium vessels with grade 1 and 2 stenosis (grade 4 stenosis is rare), and the imaging features generally show centripetal and moderate enhancement, suggesting that this feature is specific for the diagnosis of CNSV. High-grade stenosis, concentric enhancement and strong enhancement of the vasculature indicate more severe disease activity. Remarkably, HR-VWI proved to be significantly more sensitive than magnetic resonance angiography in detecting CNSV. Among the 13 cases subjected to imaging review, 8 demonstrated a reduction or resolution of vessel wall inflammation. In contrast, five patients exhibited worsening inflammation in the vessel wall. HR-VWI demonstrated that changes in vessel wall inflammation were closely correlated with changes in brain parenchymal lesions and symptoms | ||
| 520 | |a Conclusion: This study underscores the diagnostic value of HR-VWI in CNSV assessment and treatment monitoring, offering a quantitative evaluation of CNSV in children | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a HR-VWI | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a central nervous system vasculitis | |
| 650 | 4 | |a children | |
| 700 | 1 | |a Sun, Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Yi, Zexi |e verfasserin |4 aut | |
| 700 | 1 | |a Meng, Weixin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Xueying |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Xuran |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Pingyong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Sicong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Mingfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Lixia |e verfasserin |4 aut | |
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