Clinical and nutritional correlates of bacterial diarrhoea aetiology in young children : a secondary cross-sectional analysis of the ABCD trial
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ..
OBJECTIVE: The objective was to assess the association between nutritional and clinical characteristics and quantitative PCR (qPCR)-diagnosis of bacterial diarrhoea in a multicentre cohort of children under 2 years of age with moderate to severe diarrhoea (MSD).
DESIGN: A secondary cross-sectional analysis of baseline data collected from the AntiBiotics for Children with Diarrhoea trial (NCT03130114).
PATIENTS: Children with MSD (defined as >3 loose stools within 24 hours and presenting with at least one of the following: some/severe dehydration, moderate acute malnutrition (MAM) or severe stunting) enrolled in the ABCD trial and collected stool sample.
STUDY PERIOD: June 2017-July 2019.
INTERVENTIONS: None.
MAIN OUTCOME MEASURES: Likely bacterial aetiology of diarrhoea. Secondary outcomes included specific diarrhoea aetiology.
RESULTS: A total of 6692 children with MSD had qPCR results available and 28% had likely bacterial diarrhoea aetiology. Compared with children with severe stunting, children with MAM (adjusted OR (aOR) (95% CI) 1.56 (1.18 to 2.08)), some/severe dehydration (aOR (95% CI) 1.66 (1.25 to 2.22)) or both (aOR (95% CI) 2.21 (1.61 to 3.06)), had higher odds of having likely bacterial diarrhoea aetiology. Similar trends were noted for stable toxin-enterotoxigenic Escherichia coli aetiology. Clinical correlates including fever and prolonged duration of diarrhoea were not associated with likely bacterial aetiology; children with more than six stools in the previous 24 hours had higher odds of likely bacterial diarrhoea (aOR (95% CI) 1.20 (1.05 to 1.36)) compared with those with fewer stools.
CONCLUSION: The presence of MAM, dehydration or high stool frequency may be helpful in identifying children with MSD who might benefit from antibiotics.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
|---|---|
| Enthalten in: |
BMJ paediatrics open - 8(2024), 1 vom: 11. Apr. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Somji, Sarah [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 15.04.2024 Date Revised 25.04.2024 published: Electronic ClinicalTrials.gov: NCT03130114 Citation Status MEDLINE |
|---|
| doi: |
10.1136/bmjpo-2023-002448 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM37094089X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM37094089X | ||
| 003 | DE-627 | ||
| 005 | 20240425233927.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240412s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1136/bmjpo-2023-002448 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1386.xml |
| 035 | |a (DE-627)NLM37094089X | ||
| 035 | |a (NLM)38604769 | ||
| 035 | |a (PII)e002448 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Somji, Sarah |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical and nutritional correlates of bacterial diarrhoea aetiology in young children |b a secondary cross-sectional analysis of the ABCD trial |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 15.04.2024 | ||
| 500 | |a Date Revised 25.04.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT03130114 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ. | ||
| 520 | |a OBJECTIVE: The objective was to assess the association between nutritional and clinical characteristics and quantitative PCR (qPCR)-diagnosis of bacterial diarrhoea in a multicentre cohort of children under 2 years of age with moderate to severe diarrhoea (MSD) | ||
| 520 | |a DESIGN: A secondary cross-sectional analysis of baseline data collected from the AntiBiotics for Children with Diarrhoea trial (NCT03130114) | ||
| 520 | |a PATIENTS: Children with MSD (defined as >3 loose stools within 24 hours and presenting with at least one of the following: some/severe dehydration, moderate acute malnutrition (MAM) or severe stunting) enrolled in the ABCD trial and collected stool sample | ||
| 520 | |a STUDY PERIOD: June 2017-July 2019 | ||
| 520 | |a INTERVENTIONS: None | ||
| 520 | |a MAIN OUTCOME MEASURES: Likely bacterial aetiology of diarrhoea. Secondary outcomes included specific diarrhoea aetiology | ||
| 520 | |a RESULTS: A total of 6692 children with MSD had qPCR results available and 28% had likely bacterial diarrhoea aetiology. Compared with children with severe stunting, children with MAM (adjusted OR (aOR) (95% CI) 1.56 (1.18 to 2.08)), some/severe dehydration (aOR (95% CI) 1.66 (1.25 to 2.22)) or both (aOR (95% CI) 2.21 (1.61 to 3.06)), had higher odds of having likely bacterial diarrhoea aetiology. Similar trends were noted for stable toxin-enterotoxigenic Escherichia coli aetiology. Clinical correlates including fever and prolonged duration of diarrhoea were not associated with likely bacterial aetiology; children with more than six stools in the previous 24 hours had higher odds of likely bacterial diarrhoea (aOR (95% CI) 1.20 (1.05 to 1.36)) compared with those with fewer stools | ||
| 520 | |a CONCLUSION: The presence of MAM, dehydration or high stool frequency may be helpful in identifying children with MSD who might benefit from antibiotics | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a infant | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 700 | 1 | |a Ashorn, Per |e verfasserin |4 aut | |
| 700 | 1 | |a Manji, Karim |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmed, Tahmeed |e verfasserin |4 aut | |
| 700 | 1 | |a Chisti, Md |e verfasserin |4 aut | |
| 700 | 1 | |a Dhingra, Usha |e verfasserin |4 aut | |
| 700 | 1 | |a Sazawal, Sunil |e verfasserin |4 aut | |
| 700 | 1 | |a Singa, Benson |e verfasserin |4 aut | |
| 700 | 1 | |a Walson, Judd L |e verfasserin |4 aut | |
| 700 | 1 | |a Pavlinac, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Bar-Zeev, Naor |e verfasserin |4 aut | |
| 700 | 1 | |a Houpt, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Dube, Queen |e verfasserin |4 aut | |
| 700 | 1 | |a Kotloff, Karen |e verfasserin |4 aut | |
| 700 | 1 | |a Sow, Samba |e verfasserin |4 aut | |
| 700 | 1 | |a Yousafzai, Mohammad Tahir |e verfasserin |4 aut | |
| 700 | 1 | |a Qamar, Farah |e verfasserin |4 aut | |
| 700 | 1 | |a Bahl, Rajiv |e verfasserin |4 aut | |
| 700 | 1 | |a De Costa, Ayesha |e verfasserin |4 aut | |
| 700 | 1 | |a Simon, Jonathon |e verfasserin |4 aut | |
| 700 | 1 | |a Sudfeld, Christopher R |e verfasserin |4 aut | |
| 700 | 1 | |a Duggan, Christopher P |e verfasserin |4 aut | |
| 700 | 0 | |a ABCD Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Rahman, Muhammad Waliur |e investigator |4 oth | |
| 700 | 1 | |a Parvin, Irin |e investigator |4 oth | |
| 700 | 1 | |a Kabir, Md Farhad |e investigator |4 oth | |
| 700 | 1 | |a Dhingra, Pratibha |e investigator |4 oth | |
| 700 | 1 | |a Dutta, Arup |e investigator |4 oth | |
| 700 | 1 | |a Sharma, Anil Kumar |e investigator |4 oth | |
| 700 | 1 | |a Jaiswal, Vijay Kumar |e investigator |4 oth | |
| 700 | 1 | |a Nyabinda, Churchil |e investigator |4 oth | |
| 700 | 1 | |a McGrath, Christine |e investigator |4 oth | |
| 700 | 1 | |a Deichsel, Emily L |e investigator |4 oth | |
| 700 | 1 | |a Anyango, Maurine |e investigator |4 oth | |
| 700 | 1 | |a Kariuki, Kevin Mwangi |e investigator |4 oth | |
| 700 | 1 | |a Rwigi, Doreen |e investigator |4 oth | |
| 700 | 1 | |a Tornberg-Belanger, Stephanie N |e investigator |4 oth | |
| 700 | 1 | |a Haidara, Fadima Cheick |e investigator |4 oth | |
| 700 | 1 | |a Coulibaly, Flanon |e investigator |4 oth | |
| 700 | 1 | |a Permala-Booth, Jasnehta |e investigator |4 oth | |
| 700 | 1 | |a Malle, Dramane |e investigator |4 oth | |
| 700 | 1 | |a Cunliffe, Nigel |e investigator |4 oth | |
| 700 | 1 | |a Ndeketa, Latif |e investigator |4 oth | |
| 700 | 1 | |a Witte, Desiree |e investigator |4 oth | |
| 700 | 1 | |a Ndamala, Chifundo |e investigator |4 oth | |
| 700 | 1 | |a Qureshi, Shahida |e investigator |4 oth | |
| 700 | 1 | |a Shakoor, Sadia |e investigator |4 oth | |
| 700 | 1 | |a Thobani, Rozina |e investigator |4 oth | |
| 700 | 1 | |a Mohammed, Jan |e investigator |4 oth | |
| 700 | 1 | |a Kisenge, Rodrick |e investigator |4 oth | |
| 700 | 1 | |a Bakari, Mohamed |e investigator |4 oth | |
| 700 | 1 | |a Msemwa, Cecylia |e investigator |4 oth | |
| 700 | 1 | |a Samma, Abraham |e investigator |4 oth | |
| 700 | 1 | |a Platts-Mills, James |e investigator |4 oth | |
| 700 | 1 | |a Liu, Jie |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t BMJ paediatrics open |d 2017 |g 8(2024), 1 vom: 11. Apr. |w (DE-627)NLM277860482 |x 2399-9772 |7 nnns |
| 773 | 1 | 8 | |g volume:8 |g year:2024 |g number:1 |g day:11 |g month:04 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1136/bmjpo-2023-002448 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 8 |j 2024 |e 1 |b 11 |c 04 | ||