Unveiling potent Schiff base derivatives with selective xanthine oxidase inhibition : In silico and in vitro approach
© 2024 The Author(s)..
This research describes the synthesis by an environmentally-friendly method, microwave irradiation, development and analysis of three novel and one previously identified Schiff base derivative as a potential inhibitor of bovine xanthine oxidase (BXO), a key enzyme implicated in the progression of gout. Meticulous experimentation revealed that these compounds (10, 9, 4, and 7) have noteworthy inhibitory effects on BXO, with IC50 values ranging from 149.56 µM to 263.60 µM, indicating their good efficacy compared to that of the standard control. The validation of these results was further enhanced through comprehensive in silico studies, which revealed the pivotal interactions between the inhibitors and the catalytic sites of BXO, with a particular emphasis on the imine group (-C = N-) functionalities. Intriguingly, the compounds exhibiting the highest inhibition rates also showcase advantageous ADMET profiles, alongside encouraging initial assessments via PASS, hinting at their broad-spectrum potential. The implications of these findings are profound, suggesting that these Schiff base derivatives not only offer a new vantage point for the inhibition of BXO but also hold considerable promise as innovative therapeutic agents in the management and treatment of gout, marking a significant leap forward in the quest for more effective gout interventions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society - 32(2024), 5 vom: 20. Apr., Seite 102062 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bellahcene, Fatna [VerfasserIn] |
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| Links: |
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| Themen: |
Gout |
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| Anmerkungen: |
Date Revised 25.04.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.jsps.2024.102062 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370912969 |
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| 520 | |a © 2024 The Author(s). | ||
| 520 | |a This research describes the synthesis by an environmentally-friendly method, microwave irradiation, development and analysis of three novel and one previously identified Schiff base derivative as a potential inhibitor of bovine xanthine oxidase (BXO), a key enzyme implicated in the progression of gout. Meticulous experimentation revealed that these compounds (10, 9, 4, and 7) have noteworthy inhibitory effects on BXO, with IC50 values ranging from 149.56 µM to 263.60 µM, indicating their good efficacy compared to that of the standard control. The validation of these results was further enhanced through comprehensive in silico studies, which revealed the pivotal interactions between the inhibitors and the catalytic sites of BXO, with a particular emphasis on the imine group (-C = N-) functionalities. Intriguingly, the compounds exhibiting the highest inhibition rates also showcase advantageous ADMET profiles, alongside encouraging initial assessments via PASS, hinting at their broad-spectrum potential. The implications of these findings are profound, suggesting that these Schiff base derivatives not only offer a new vantage point for the inhibition of BXO but also hold considerable promise as innovative therapeutic agents in the management and treatment of gout, marking a significant leap forward in the quest for more effective gout interventions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Gout | |
| 650 | 4 | |a In silico approach | |
| 650 | 4 | |a Schiff base | |
| 650 | 4 | |a Triazole | |
| 650 | 4 | |a Xanthine oxidase inhibition | |
| 700 | 1 | |a Benarous, Khedidja |e verfasserin |4 aut | |
| 700 | 1 | |a Mermer, Arif |e verfasserin |4 aut | |
| 700 | 1 | |a Boulebd, Houssem |e verfasserin |4 aut | |
| 700 | 1 | |a Serseg, Talia |e verfasserin |4 aut | |
| 700 | 1 | |a Linani, Abderahmane |e verfasserin |4 aut | |
| 700 | 1 | |a Kaouka, Alaeddine |e verfasserin |4 aut | |
| 700 | 1 | |a Yousfi, Mohamed |e verfasserin |4 aut | |
| 700 | 1 | |a Syed, Asad |e verfasserin |4 aut | |
| 700 | 1 | |a Elgorban, Abdallah M |e verfasserin |4 aut | |
| 700 | 1 | |a Ozeki, Yasuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kawsar, Sarkar M A |e verfasserin |4 aut | |
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