Prognostic effects of different treatment modalities for hypopharyngeal squamous cell carcinoma : Experience of two tertiary hospitals in Southwestern China
© 2024 The Authors..
Background: The prognostic effects of different treatment modalities on patients with hypopharyngeal squamous cell carcinoma (HPSCC) remain unclear.
Methods: HPSCC patients diagnosed and treated at either West China Hospital or Sichuan Cancer Hospital between January 1, 2009, and December 31, 2019, were enrolled in this retrospective, real-world study. Survival rates were presented using Kaplan-Meier curves and compared using log-rank tests. Univariable and multivariable Cox proportional hazards regression models were used to identify the predictors of overall survival (OS). Subgroup analyses were conducted for patients with advanced-stage HPSCC (stages III and IV and category T4).
Results: A total of 527 patients with HPSCC were included. Patients receiving SRC (surgery, radiotherapy [RT], and chemotherapy) showed the best OS (p < 0.0001). In comparison with RT alone, both surgery alone (all cases: hazard ratio [HR] = 0.39, p = 0.0018; stage IV cases: HR = 0.38, p = 0.0085) and surgery-based multimodality treatment (SBMT; all cases: HR = 0.27, p < 0.0001; stage IV cases: HR = 0.30, p = 0.00025) showed prognostic benefits, while SBMT also showed survival priority over chemoradiotherapy (CRT; all cases: HR = 0.52, p < 0.0001; stage IV cases: HR = 0.59, p = 0.0033). Moreover, patients who underwent surgery alone had comparable OS to those who underwent SBMT (all patients: p = 0.13; stage IV cases: p = 0.34), while CRT yielded similar prognostic outcomes as RT alone (all patients: p = 0.054; stage IV cases: p = 0.11).
Conclusions: Surgery alone was comparable to SBMT and superior to RT/CRT in terms of OS in patients with HPSCC. We suggest that surgery should be encouraged for the treatment of HPSCC, even in patients with advanced-stage disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Heliyon - 10(2024), 7 vom: 15. Apr., Seite e28496 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Junhong [VerfasserIn] |
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| Links: |
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| Themen: |
Chemoradiotherapy |
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| Anmerkungen: |
Date Revised 25.04.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.heliyon.2024.e28496 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370908457 |
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| 100 | 1 | |a Li, Junhong |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic effects of different treatment modalities for hypopharyngeal squamous cell carcinoma |b Experience of two tertiary hospitals in Southwestern China |
| 264 | 1 | |c 2024 | |
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| 500 | |a published: Electronic-eCollection | ||
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| 520 | |a © 2024 The Authors. | ||
| 520 | |a Background: The prognostic effects of different treatment modalities on patients with hypopharyngeal squamous cell carcinoma (HPSCC) remain unclear | ||
| 520 | |a Methods: HPSCC patients diagnosed and treated at either West China Hospital or Sichuan Cancer Hospital between January 1, 2009, and December 31, 2019, were enrolled in this retrospective, real-world study. Survival rates were presented using Kaplan-Meier curves and compared using log-rank tests. Univariable and multivariable Cox proportional hazards regression models were used to identify the predictors of overall survival (OS). Subgroup analyses were conducted for patients with advanced-stage HPSCC (stages III and IV and category T4) | ||
| 520 | |a Results: A total of 527 patients with HPSCC were included. Patients receiving SRC (surgery, radiotherapy [RT], and chemotherapy) showed the best OS (p < 0.0001). In comparison with RT alone, both surgery alone (all cases: hazard ratio [HR] = 0.39, p = 0.0018; stage IV cases: HR = 0.38, p = 0.0085) and surgery-based multimodality treatment (SBMT; all cases: HR = 0.27, p < 0.0001; stage IV cases: HR = 0.30, p = 0.00025) showed prognostic benefits, while SBMT also showed survival priority over chemoradiotherapy (CRT; all cases: HR = 0.52, p < 0.0001; stage IV cases: HR = 0.59, p = 0.0033). Moreover, patients who underwent surgery alone had comparable OS to those who underwent SBMT (all patients: p = 0.13; stage IV cases: p = 0.34), while CRT yielded similar prognostic outcomes as RT alone (all patients: p = 0.054; stage IV cases: p = 0.11) | ||
| 520 | |a Conclusions: Surgery alone was comparable to SBMT and superior to RT/CRT in terms of OS in patients with HPSCC. We suggest that surgery should be encouraged for the treatment of HPSCC, even in patients with advanced-stage disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chemoradiotherapy | |
| 650 | 4 | |a Curative treatment | |
| 650 | 4 | |a Hypopharyngeal squamous cell carcinoma | |
| 650 | 4 | |a Overall survival | |
| 650 | 4 | |a Surgery-based multimodality treatment | |
| 700 | 1 | |a He, Shanshan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jifeng |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Di |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Yijun |e verfasserin |4 aut | |
| 700 | 1 | |a Pang, Wendu |e verfasserin |4 aut | |
| 700 | 1 | |a Minzi, Mao |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Rao, Yufang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Xinyin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Shichuan |e verfasserin |4 aut | |
| 700 | 1 | |a Jianjun, Ren |e verfasserin |4 aut | |
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