On-site detection of infectious disease based on CaCO3-based magnetic micromotor integrated with graphene field effect transistor
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature..
A new detection platform based on CaCO3-based magnetic micromotor (CaCO3Fe3O4) integrated with graphene field effect transistor (GFET) was construct and used for on-site SARS-CoV-2 coronavirus pathogen detection. The CaCO3@Fe3O4 micromotor, which was modified with anti-SARS-CoV-2 (labelled antibody, AntiE1), can self-moved in the solution containing hydrochloric acid (HCl) and effective to capture the SARS-CoV-2 coronavirus pathogens. After magnetic field separation, the capture micromotor was detected by GFET, exhibiting a good linear relationship within the range of 1 ag/mL to 100 ng/mL and low detection limit (0.39 ag/mL). Furthermore, the detection platform was also successfully applied to detection of SARS-CoV-2 coronavirus pathogens in soil solution, indicating the potential use in on-site application.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:191 |
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| Enthalten in: |
Mikrochimica acta - 191(2024), 5 vom: 11. Apr., Seite 257 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Yushuang [VerfasserIn] |
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| Links: |
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| Themen: |
7782-42-5 |
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| Anmerkungen: |
Date Completed 12.04.2024 Date Revised 16.04.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00604-024-06345-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM370897390 |
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| 520 | |a A new detection platform based on CaCO3-based magnetic micromotor (CaCO3Fe3O4) integrated with graphene field effect transistor (GFET) was construct and used for on-site SARS-CoV-2 coronavirus pathogen detection. The CaCO3@Fe3O4 micromotor, which was modified with anti-SARS-CoV-2 (labelled antibody, AntiE1), can self-moved in the solution containing hydrochloric acid (HCl) and effective to capture the SARS-CoV-2 coronavirus pathogens. After magnetic field separation, the capture micromotor was detected by GFET, exhibiting a good linear relationship within the range of 1 ag/mL to 100 ng/mL and low detection limit (0.39 ag/mL). Furthermore, the detection platform was also successfully applied to detection of SARS-CoV-2 coronavirus pathogens in soil solution, indicating the potential use in on-site application | ||
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| 700 | 1 | |a Hai, Wenfeng |e verfasserin |4 aut | |
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