Metabolic adaptations in cancer stem cells : A key to therapy resistance
Copyright © 2024 Elsevier B.V. All rights reserved..
Cancer stem cells (CSCs) are a subset of tumor cells that can initiate and sustain tumor growth and cause recurrence and metastasis. CSCs are particularly resistant to conventional therapies compared to their counterparts, owing greatly to their intrinsic metabolic plasticity. Metabolic plasticity allows CSCs to switch between different energy production and usage pathways based on environmental and extrinsic factors, including conditions imposed by conventional cancer therapies. To cope with nutrient deprivation and therapeutic stress, CSCs can transpose between glycolysis and oxidative phosphorylation (OXPHOS) metabolism. The mechanism behind the metabolic pathway switch in CSCs is not fully understood, however, some evidence suggests that the tumor microenvironment (TME) may play an influential role mediated by its release of signals, such as Wnt/β-catenin and Notch pathways, as well as a background of hypoxia. Exploring the factors that promote metabolic plasticity in CSCs offers the possibility of eventually developing therapies that may more effectively eliminate the crucial tumor cell subtype and alter the disease course substantially.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1870 |
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| Enthalten in: |
Biochimica et biophysica acta. Molecular basis of disease - 1870(2024), 5 vom: 09. Apr., Seite 167164 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Masoudi, Matthew [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer stem cells |
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| Anmerkungen: |
Date Revised 19.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.bbadis.2024.167164 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a Cancer stem cells (CSCs) are a subset of tumor cells that can initiate and sustain tumor growth and cause recurrence and metastasis. CSCs are particularly resistant to conventional therapies compared to their counterparts, owing greatly to their intrinsic metabolic plasticity. Metabolic plasticity allows CSCs to switch between different energy production and usage pathways based on environmental and extrinsic factors, including conditions imposed by conventional cancer therapies. To cope with nutrient deprivation and therapeutic stress, CSCs can transpose between glycolysis and oxidative phosphorylation (OXPHOS) metabolism. The mechanism behind the metabolic pathway switch in CSCs is not fully understood, however, some evidence suggests that the tumor microenvironment (TME) may play an influential role mediated by its release of signals, such as Wnt/β-catenin and Notch pathways, as well as a background of hypoxia. Exploring the factors that promote metabolic plasticity in CSCs offers the possibility of eventually developing therapies that may more effectively eliminate the crucial tumor cell subtype and alter the disease course substantially | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Cancer stem cells | |
| 650 | 4 | |a Glycolysis | |
| 650 | 4 | |a Metabolic plasticity | |
| 650 | 4 | |a Metastasis | |
| 650 | 4 | |a Oxidative phosphorylation | |
| 650 | 4 | |a Recurrence | |
| 650 | 4 | |a Tumor microenvironment | |
| 700 | 1 | |a Moti, Dilpreet |e verfasserin |4 aut | |
| 700 | 1 | |a Masoudi, Raha |e verfasserin |4 aut | |
| 700 | 1 | |a Auwal, Abdul |e verfasserin |4 aut | |
| 700 | 1 | |a Hossain, M Matakabbir |e verfasserin |4 aut | |
| 700 | 1 | |a Pronoy, Tasfik Ul Haque |e verfasserin |4 aut | |
| 700 | 1 | |a Rashel, Khan Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Gopalan, Vinod |e verfasserin |4 aut | |
| 700 | 1 | |a Islam, Farhadul |e verfasserin |4 aut | |
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