Significance of preoperative exercise oxygen desaturation in lung cancer with interstitial lung disease
© The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved..
OBJECTIVES: Evaluating the diffusing capacity for carbon monoxide (DLco) is crucial for patients with lung cancer and interstitial lung disease. However, the clinical significance of assessing exercise oxygen desaturation (EOD) remains unclear.
METHODS: We retrospectively analyzed 186 consecutive patients with interstitial lung disease who underwent lobectomy for non-small cell lung cancer. EOD was assessed using two-flight test (TFT), with TFT positivity defined as ≥ 5% SpO2 reduction. We investigated the impact of EOD and predicted postoperative (ppo) %DLco on postoperative complications and prognosis.
RESULTS: A total of 106 (57%) patients were identified as TFT-positive, and 58 (31%) patients had ppo% DLco < 30%. Pulmonary complications were significantly more prevalent in TFT-positive patients than in TFT-negative patients (52% vs 19%, P < 0.001), and multivariable analysis revealed that TFT-positivity was an independent risk factor (odds ratio 3.46, 95% confidence interval 1.70-7.07, P < 0.001), while ppo%DLco was not (P = 0.09). In terms of long-term outcomes, both TFT positivity and ppo%DLco < 30% independently predicted overall survival. We divided the patients into four groups based on TFT positivity and ppo%DLco status. TFT-positive patients with ppo%DLco < 30% exhibited the significantly lowest 5-year overall survival among four groups: ppo%DLco ≥ 30% and TFT-negative, 54.2%; ppo%DLco < 30% and TFT-negative, 68.8%; ppo%DLco ≥ 30% and TFT-positive, 38.1%; and ppo%DLco < 30% and TFT-positive, 16.7% (P = 0.001).
CONCLUSIONS: Incorporating EOD evaluation was useful for predicting postoperative complications and survival outcomes in patients with lung cancer and interstitial lung disease.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery - (2024) vom: 10. Apr. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ueda, Takuya [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Diffusing capacity for carbon monoxide |
|---|
| Anmerkungen: |
Date Revised 10.04.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1093/ejcts/ezae142 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM370877748 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM370877748 | ||
| 003 | DE-627 | ||
| 005 | 20240411233048.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240411s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/ejcts/ezae142 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1372.xml |
| 035 | |a (DE-627)NLM370877748 | ||
| 035 | |a (NLM)38598441 | ||
| 035 | |a (PII)ezae142 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ueda, Takuya |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Significance of preoperative exercise oxygen desaturation in lung cancer with interstitial lung disease |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 10.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. | ||
| 520 | |a OBJECTIVES: Evaluating the diffusing capacity for carbon monoxide (DLco) is crucial for patients with lung cancer and interstitial lung disease. However, the clinical significance of assessing exercise oxygen desaturation (EOD) remains unclear | ||
| 520 | |a METHODS: We retrospectively analyzed 186 consecutive patients with interstitial lung disease who underwent lobectomy for non-small cell lung cancer. EOD was assessed using two-flight test (TFT), with TFT positivity defined as ≥ 5% SpO2 reduction. We investigated the impact of EOD and predicted postoperative (ppo) %DLco on postoperative complications and prognosis | ||
| 520 | |a RESULTS: A total of 106 (57%) patients were identified as TFT-positive, and 58 (31%) patients had ppo% DLco < 30%. Pulmonary complications were significantly more prevalent in TFT-positive patients than in TFT-negative patients (52% vs 19%, P < 0.001), and multivariable analysis revealed that TFT-positivity was an independent risk factor (odds ratio 3.46, 95% confidence interval 1.70-7.07, P < 0.001), while ppo%DLco was not (P = 0.09). In terms of long-term outcomes, both TFT positivity and ppo%DLco < 30% independently predicted overall survival. We divided the patients into four groups based on TFT positivity and ppo%DLco status. TFT-positive patients with ppo%DLco < 30% exhibited the significantly lowest 5-year overall survival among four groups: ppo%DLco ≥ 30% and TFT-negative, 54.2%; ppo%DLco < 30% and TFT-negative, 68.8%; ppo%DLco ≥ 30% and TFT-positive, 38.1%; and ppo%DLco < 30% and TFT-positive, 16.7% (P = 0.001) | ||
| 520 | |a CONCLUSIONS: Incorporating EOD evaluation was useful for predicting postoperative complications and survival outcomes in patients with lung cancer and interstitial lung disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a diffusing capacity for carbon monoxide | |
| 650 | 4 | |a exercise oxygen desaturation | |
| 650 | 4 | |a interstitial lung disease | |
| 650 | 4 | |a lung cancer | |
| 650 | 4 | |a pulmonary resection | |
| 700 | 1 | |a Takamochi, Kazuya |e verfasserin |4 aut | |
| 700 | 1 | |a Fukui, Mariko |e verfasserin |4 aut | |
| 700 | 1 | |a Ichikawa, Tomohiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hattori, Aritoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Matsunaga, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Shiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Tomita, Hisashi |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Kenji |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery |d 1996 |g (2024) vom: 10. Apr. |w (DE-627)NLM012606200 |x 1873-734X |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:10 |g month:04 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/ejcts/ezae142 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 10 |c 04 | ||