Islr regulates satellite cells asymmetric division through the SPARC/p-ERK1/2 signaling pathway
© 2024 Federation of American Societies for Experimental Biology..
Satellite cells (SCs) are adult muscle stem cells responsible for muscle regeneration after acute and chronic muscle injuries. The balance between stem cell self-renewal and differentiation determines the kinetics and efficiency of skeletal muscle regeneration. This study assessed the function of Islr in SC asymmetric division. The deletion of Islr reduced muscle regeneration in adult mice by decreasing the SC pool. Islr is pivotal for SC proliferation, and its deletion promoted the asymmetric division of SCs. A mechanistic search revealed that Islr bound to and degraded secreted protein acidic and rich in cysteine (SPARC), which activated p-ERK1/2 signaling required for asymmetric division. These findings demonstrate that Islr is a key regulator of SC division through the SPARC/p-ERK1/2 signaling pathway. These data provide a basis for treating myopathy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
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| Enthalten in: |
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 38(2024), 7 vom: 15. Apr., Seite e23534 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Fan [VerfasserIn] |
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| Anmerkungen: |
Date Completed 11.04.2024 Date Revised 24.04.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1096/fj.202302614R |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370872436 |
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| 245 | 1 | 0 | |a Islr regulates satellite cells asymmetric division through the SPARC/p-ERK1/2 signaling pathway |
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| 520 | |a © 2024 Federation of American Societies for Experimental Biology. | ||
| 520 | |a Satellite cells (SCs) are adult muscle stem cells responsible for muscle regeneration after acute and chronic muscle injuries. The balance between stem cell self-renewal and differentiation determines the kinetics and efficiency of skeletal muscle regeneration. This study assessed the function of Islr in SC asymmetric division. The deletion of Islr reduced muscle regeneration in adult mice by decreasing the SC pool. Islr is pivotal for SC proliferation, and its deletion promoted the asymmetric division of SCs. A mechanistic search revealed that Islr bound to and degraded secreted protein acidic and rich in cysteine (SPARC), which activated p-ERK1/2 signaling required for asymmetric division. These findings demonstrate that Islr is a key regulator of SC division through the SPARC/p-ERK1/2 signaling pathway. These data provide a basis for treating myopathy | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Islr protein, mouse |2 NLM | |
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| 700 | 1 | |a Wang, Xiong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Kuo |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Na |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yali |e verfasserin |4 aut | |
| 700 | 1 | |a Meng, Qingyong |e verfasserin |4 aut | |
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