Association between obesity and cancer risk in HIV-infected Asians
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved..
INTRODUCTION: This study aimed to investigate the association between obesity and cancer risk as well as site-specific cancer risks in adults with HIV using a nationwide health screening database in Korea.
METHODS: Of the 16,671 adults with a new diagnosis of HIV from 2004 to 2020, 456 incident cancer cases and 1,814 individually matched controls by sex, year of birth, year of HIV diagnosis, and follow-up duration (1:4 ratio) were included in this nested case-control study. The association between obesity (body mass index ≥25 kg/m2) and cancer risks was estimated and presented as odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS: Of the 456 cancer incident cases, there were 146 AIDS-defining cancer cases and 310 non-AIDS-defining cancer cases. Compared with non-obese adults with HIV, obese adults with HIV were at higher risk of non-AIDS-defining cancer (OR = 1.478, 95% CI = 1.118-1.955). Otherwise, the overall risk of AIDS-defining cancer (OR = 0.816, 95% CI = 0.520-1.279) and each type of AIDS-defining cancer (Kaposi sarcoma and non-Hodgkin's lymphoma) were not high in obese adults with HIV. Of the specific types of non-AIDS-defining cancers, obesity was associated with an increased risk of colorectal cancer (OR = 3.090, 95% CI = 1.110-8.604) and liver, bile duct, and pancreatic cancers (OR = 2.532, 95% CI = 1.141-5.617).
CONCLUSIONS: Obesity, which is one of the important health concerns in HIV management, was associated with an increased risk of non-AIDS-defining cancer but not AIDS-defining cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
AIDS (London, England) - (2024) vom: 10. Apr. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jang, Yoonyoung [VerfasserIn] |
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| Anmerkungen: |
Date Revised 10.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1097/QAD.0000000000003904 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM370868471 |
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| 520 | |a Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved. | ||
| 520 | |a INTRODUCTION: This study aimed to investigate the association between obesity and cancer risk as well as site-specific cancer risks in adults with HIV using a nationwide health screening database in Korea | ||
| 520 | |a METHODS: Of the 16,671 adults with a new diagnosis of HIV from 2004 to 2020, 456 incident cancer cases and 1,814 individually matched controls by sex, year of birth, year of HIV diagnosis, and follow-up duration (1:4 ratio) were included in this nested case-control study. The association between obesity (body mass index ≥25 kg/m2) and cancer risks was estimated and presented as odds ratios (ORs) and 95% confidence intervals (CIs) | ||
| 520 | |a RESULTS: Of the 456 cancer incident cases, there were 146 AIDS-defining cancer cases and 310 non-AIDS-defining cancer cases. Compared with non-obese adults with HIV, obese adults with HIV were at higher risk of non-AIDS-defining cancer (OR = 1.478, 95% CI = 1.118-1.955). Otherwise, the overall risk of AIDS-defining cancer (OR = 0.816, 95% CI = 0.520-1.279) and each type of AIDS-defining cancer (Kaposi sarcoma and non-Hodgkin's lymphoma) were not high in obese adults with HIV. Of the specific types of non-AIDS-defining cancers, obesity was associated with an increased risk of colorectal cancer (OR = 3.090, 95% CI = 1.110-8.604) and liver, bile duct, and pancreatic cancers (OR = 2.532, 95% CI = 1.141-5.617) | ||
| 520 | |a CONCLUSIONS: Obesity, which is one of the important health concerns in HIV management, was associated with an increased risk of non-AIDS-defining cancer but not AIDS-defining cancer | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Kim, Taehwa |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Yunsu |e verfasserin |4 aut | |
| 700 | 1 | |a Ahn, Kyoung Hwan |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jung Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Seong, Hye |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Youn Jeong |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Shin-Woo |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Jun Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hyo Youl |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Joon Young |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Hee Jung |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Sang Il |e verfasserin |4 aut | |
| 700 | 1 | |a Sohn, Jang Wook |e verfasserin |4 aut | |
| 700 | 1 | |a Chin, BumSik |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Bo-Youl |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Boyoung |e verfasserin |4 aut | |
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